{"id":"W2346650719","doi":"10.1093/ntr/ntw129","title":"The Effect of Different Case Definitions of Current Smoking on the Discovery of Smoking-Related Blood Gene Expression Signatures in Chronic Obstructive Pulmonary Disease","year":2016,"lang":"en","type":"article","venue":"Nicotine & Tobacco Research","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Prevention of Organ Failure; St. Paul's Hospital; University of British Columbia","funders":"Reseau canadien de recherche respiratoire; GlaxoSmithKline; Michael Smith Health Research BC; Canadian Institutes of Health Research; Genome Canada; Canada Research Chairs","keywords":"COPD; Gene expression; Medicine; Gene expression profiling; Gene; Disease; Pulmonary disease; Bioinformatics; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008495779,0.00018442,0.0002266334,0.0001051371,0.000136381,0.00001412186,0.0003791793,0.0001211837,0.00001812212],"category_scores_gemma":[0.0007349155,0.00008603209,0.0001870685,0.0002226989,0.0003903204,0.000008691806,0.0003472322,0.0003519221,4.774572e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006221624,"about_ca_system_score_gemma":0.0001679409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004258365,"about_ca_topic_score_gemma":0.00005756954,"domain_scores_codex":[0.9975673,0.0007996953,0.0004135139,0.0003504014,0.000486121,0.000382997],"domain_scores_gemma":[0.9980733,0.0008293801,0.0001710234,0.0007052069,0.0001399631,0.0000811366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004500725,0.0001987421,0.03628394,0.0000736029,0.00006718286,0.00002771041,0.00002078533,0.00006452996,0.9574953,0.0005689458,0.00007005681,0.004679138],"study_design_scores_gemma":[0.0008188668,0.0005877194,0.02889095,0.0003884377,0.00003614835,0.000007299949,0.00004905315,0.00001824577,0.9687497,0.0003044503,0.00004932245,0.00009979784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933599,0.005666095,0.000008138551,0.0001180224,0.00007637088,0.0004716087,0.000125942,0.000003659828,0.0001703102],"genre_scores_gemma":[0.9983721,0.00134079,0.000002086787,0.000003186969,0.00007568701,0.0001092763,0.00002700409,0.00002236041,0.00004744751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01125442,"threshold_uncertainty_score":0.3508286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02716755185259764,"score_gpt":0.3067080983271834,"score_spread":0.2795405464745858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}