{"id":"W2346657233","doi":"10.1158/1538-7445.am2015-2947","title":"Abstract 2947: Pharmacodynamic (PD) and pharmacokinetic (PK) results of the second-generation hypomethylating agent, SGI-110, in patients with hepatocellular carcinoma (HCC) after progression on sorafenib","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Decitabine; Sorafenib; Medicine; Hepatocellular carcinoma; Internal medicine; Oncology; Hypomethylating agent; Cancer; Pharmacodynamics; Progressive disease; Gastroenterology; Pharmacology; Pharmacokinetics; DNA methylation; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005341832,0.0004521124,0.0008883986,0.0002303854,0.0002113489,0.0003897034,0.0001874927,0.0003946712,0.001163278],"category_scores_gemma":[0.0009222848,0.0001762833,0.0004426847,0.0001640471,0.0002639216,0.0004091312,0.0001578146,0.001026877,0.0003115138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472103,"about_ca_system_score_gemma":0.0003169807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003723185,"about_ca_topic_score_gemma":0.0003627825,"domain_scores_codex":[0.9997826,0.00009115293,0.00001703462,0.00004274196,0.0000344359,0.00003198649],"domain_scores_gemma":[0.9994712,0.0001520107,0.0001223842,0.00003835201,0.00004672674,0.0001693478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4340761,0.02158318,0.1290903,0.000443996,0.001014228,0.001262308,0.0005449008,0.005397183,0.2459363,0.0001719097,0.003372503,0.1571071],"study_design_scores_gemma":[0.04113623,0.5682997,0.319534,0.0000322074,0.000946473,0.002743,0.000167761,0.009951389,0.05171529,0.0002755247,0.005117504,0.00008100794],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987734,0.0002890716,0.0002004335,0.00004899628,0.000009898949,0.00007934276,0.000177622,0.00002202222,0.0003991804],"genre_scores_gemma":[0.9987637,0.00008899144,0.0002133111,0.00006835761,0.00002017795,0.00006862757,0.0004165485,0.000006344359,0.000354139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163278,"threshold_uncertainty_score":0.003891528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06035489821808602,"score_gpt":0.3572176770704891,"score_spread":0.296862778852403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}