{"id":"W2346657233","doi":"10.1158/1538-7445.am2015-2947","title":"Abstract 2947: Pharmacodynamic (PD) and pharmacokinetic (PK) results of the second-generation hypomethylating agent, SGI-110, in patients with hepatocellular carcinoma (HCC) after progression on sorafenib","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Decitabine; Sorafenib; Medicine; Hepatocellular carcinoma; Internal medicine; Oncology; Hypomethylating agent; Cancer; Pharmacodynamics; Progressive disease; Gastroenterology; Pharmacology; Pharmacokinetics; DNA methylation; Disease; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005609734,0.0001301973,0.0001181989,0.00009954353,0.00008225059,0.00002907607,0.000182672,0.0000780396,0.00003120628],"category_scores_gemma":[0.0000425906,0.00009011501,0.00002942873,0.0002663639,0.000148997,0.00001211776,0.0001022898,0.0002409028,0.000001836259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009745969,"about_ca_system_score_gemma":0.0002249681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001115267,"about_ca_topic_score_gemma":0.0001673874,"domain_scores_codex":[0.9984711,0.0001776367,0.0002467551,0.0003888922,0.0004398064,0.0002758398],"domain_scores_gemma":[0.9991236,0.0000143485,0.000109041,0.0003309579,0.0003193002,0.0001027411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002023348,0.0001901506,0.1568987,0.00007737349,0.00002786863,0.000004898278,0.0002455751,0.0003760631,0.826612,0.00000278094,0.001300879,0.01224035],"study_design_scores_gemma":[0.005549323,0.00056121,0.3517267,0.0001316944,0.000013276,0.000001118465,0.0000635546,0.001248389,0.6347225,0.00001320485,0.00574309,0.0002259387],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970831,0.001493492,0.000005670106,0.0001756424,0.0001025222,0.0006561157,0.0001062971,0.000003216418,0.0003739637],"genre_scores_gemma":[0.9988983,0.0001060451,0.00003558145,0.00004387632,0.0001337791,0.0002672442,0.00007316038,0.0000238352,0.0004181775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.194828,"threshold_uncertainty_score":0.3674783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06035489821808602,"score_gpt":0.3572176770704891,"score_spread":0.296862778852403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}