{"id":"W2346727982","doi":"10.1182/blood-2015-03-569277","title":"HUS and the case for complement","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Blood Services; Natural Sciences and Engineering Research Council of Canada; CSL Behring","keywords":"Microangiopathic hemolytic anemia; Thrombotic microangiopathy; Complement system; Shiga toxin; Atypical hemolytic uremic syndrome; Immunology; Eculizumab; Alternative complement pathway; Hemolytic anemia; Complement (music); Coagulation; Disease; Medicine; Biology; Escherichia coli; Microbiology; Thrombotic thrombocytopenic purpura; Internal medicine; Antibody; Platelet; Phenotype; Genetics; Complementation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000699051,0.0004932806,0.0003959055,0.001060303,0.002349064,0.001304865,0.0007656355,0.005420947,0.007907636],"category_scores_gemma":[0.003480469,0.0002559637,0.0003782441,0.0006784141,0.002334435,0.002465511,0.001861818,0.004914366,0.001523639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001782614,"about_ca_system_score_gemma":0.001644678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003636856,"about_ca_topic_score_gemma":0.005801297,"domain_scores_codex":[0.9994612,0.0001055162,0.0000295408,0.00009522673,0.0001191692,0.0001892925],"domain_scores_gemma":[0.9994641,0.0001725651,0.00006570465,0.0000465655,0.00007050029,0.0001805592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001101921,0.0001232336,0.01374556,0.0002124788,0.00004605228,0.6499866,0.003347336,0.0001159635,0.00116846,0.08535662,0.1844997,0.06128782],"study_design_scores_gemma":[0.00001626439,0.00001697814,0.00182959,0.0003490358,0.00001541323,0.8505054,0.001493711,0.0001209019,0.000118847,0.02122717,0.124281,0.00002574956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.1021942,0.147642,0.003450944,0.5217013,0.01800057,0.0001660691,0.0002963047,0.0002377708,0.2063107],"genre_scores_gemma":[0.7456715,0.06242875,0.00582114,0.1110711,0.01961268,0.0001407453,0.0002133856,0.0001505431,0.05489025],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.007907636,"threshold_uncertainty_score":0.02645367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636097028928599,"score_gpt":0.2854771537793594,"score_spread":0.2391161834900734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}