{"id":"W2346727982","doi":"10.1182/blood-2015-03-569277","title":"HUS and the case for complement","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Canadian Blood Services; Natural Sciences and Engineering Research Council of Canada; CSL Behring","keywords":"Microangiopathic hemolytic anemia; Thrombotic microangiopathy; Complement system; Shiga toxin; Atypical hemolytic uremic syndrome; Immunology; Eculizumab; Alternative complement pathway; Hemolytic anemia; Complement (music); Coagulation; Disease; Medicine; Biology; Escherichia coli; Microbiology; Thrombotic thrombocytopenic purpura; Internal medicine; Antibody; Platelet; Phenotype; Genetics; Complementation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002792207,0.00005949742,0.0001094067,0.0000145596,0.0001166849,0.00001055706,0.00007348225,0.00002089063,0.0001111873],"category_scores_gemma":[0.00006904671,0.00003749273,0.00003226017,0.00001785811,0.0001050307,0.00001429065,0.00006896034,0.00002681472,0.00005508308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004833329,"about_ca_system_score_gemma":0.00001812197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001415936,"about_ca_topic_score_gemma":0.0000927535,"domain_scores_codex":[0.9995346,0.00009892893,0.0001233053,0.0001025035,0.00001103791,0.0001295891],"domain_scores_gemma":[0.9995562,0.0001930271,0.00003973068,0.0001569822,0.00003750692,0.0000164871],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002419204,0.002354289,0.04103117,0.0003008455,0.003212112,0.0004735081,0.007675363,0.000005486786,0.01121501,0.1841737,0.7406833,0.006456001],"study_design_scores_gemma":[0.1428373,0.0009251531,0.003677896,0.00005859202,0.001498214,0.01048406,0.01298885,0.00003429496,0.01541679,0.01185391,0.7996548,0.0005701699],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900548,0.006926969,0.0001204806,0.0005781089,0.0002950356,0.0008377621,0.0001393651,0.00003734788,0.001010103],"genre_scores_gemma":[0.9992672,0.000003284755,0.00007274256,0.000114422,0.00003057816,0.000139021,0.00003511633,0.000004656019,0.0003329414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1723198,"threshold_uncertainty_score":0.1528909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04636097028928599,"score_gpt":0.2854771537793594,"score_spread":0.2391161834900734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}