{"id":"W2346872653","doi":"10.1016/j.jns.2016.05.001","title":"Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial","year":2016,"lang":"en","type":"article","venue":"Journal of the Neurological Sciences","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eisai Canada; Eisai","keywords":"Donepezil; Dementia with Lewy bodies; Pharmacodynamics; Dementia; Internal medicine; Psychology; Medicine; Anesthesia; Pharmacokinetics; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003319693,0.001690032,0.003896203,0.0004597126,0.0004310162,0.001217496,0.0009114802,0.001324026,0.002437209],"category_scores_gemma":[0.00329746,0.0006778961,0.003113267,0.0006373543,0.0009765914,0.0008140008,0.000326607,0.001934605,0.000377059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007938097,"about_ca_system_score_gemma":0.001527478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007472133,"about_ca_topic_score_gemma":0.002205197,"domain_scores_codex":[0.9985766,0.0009025642,0.00008996573,0.0001623795,0.0001297401,0.0001387149],"domain_scores_gemma":[0.9981369,0.0007653326,0.0005189737,0.0001338017,0.0001262383,0.0003187224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9733536,0.006555828,0.001219657,0.0008065245,0.002598174,0.00007028314,0.00006972023,0.0004829933,0.003387554,0.00004458424,0.0002526098,0.01115839],"study_design_scores_gemma":[0.901484,0.09224304,0.003720613,0.00003438821,0.001057849,0.00004522927,0.00001528801,0.000719354,0.0004140685,0.00006871306,0.0001804768,0.00001701801],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908087,0.00379361,0.001017006,0.0003020673,0.0001276231,0.002753641,0.0005099941,0.0001044509,0.0005827728],"genre_scores_gemma":[0.9913331,0.002016183,0.001889035,0.0004291559,0.0002194681,0.003042134,0.0004165547,0.00002213512,0.0006322574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003896203,"threshold_uncertainty_score":0.01755643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494815692792835,"score_gpt":0.3045807390119308,"score_spread":0.2896325820840025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}