{"id":"W2346948763","doi":"10.1182/blood.v124.21.424.424","title":"Genetic Determinants of Busulfan Clearance and Outcomes in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation- Result of a Multicentric Prospective Study on Behalf of the Pediatric Disease Working Party of the European Blood and Marrow Transplantation Group","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; Hospital for Sick Children; SickKids Foundation; University of Toronto; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Busulfan; Melphalan; Hematopoietic stem cell transplantation; Internal medicine; Transplantation; Oncology; Hazard ratio; Fludarabine; Cyclophosphamide; Surgery; Gastroenterology; Chemotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006515787,0.0003684089,0.0004278235,0.0004582705,0.0002926041,0.0003685131,0.0002792682,0.0002898313,0.0009582575],"category_scores_gemma":[0.001281666,0.0002623974,0.0003669633,0.0008387424,0.0002663857,0.0002623799,0.0003158094,0.0003884512,0.0001772107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271555,"about_ca_system_score_gemma":0.000271478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227431,"about_ca_topic_score_gemma":0.0007515674,"domain_scores_codex":[0.9995289,0.0001659973,0.00004394147,0.0001137444,0.00008512696,0.00006236592],"domain_scores_gemma":[0.9989656,0.000173994,0.0004927453,0.00009938284,0.00008292479,0.0001852842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002097717,0.00003878972,0.9982955,0.000004070453,0.0000377546,0.0001266975,0.0000485946,0.0000501362,0.0004863575,0.00001059583,0.00003950863,0.0006522103],"study_design_scores_gemma":[0.00002158339,0.0003606401,0.9984543,0.000002413389,0.00002920302,0.0005854549,0.00007791439,0.0001702052,0.0001630822,0.000008841735,0.0001240147,0.000002261498],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997228,0.00004384265,0.00004648721,0.000006111446,0.000001125426,0.00000536608,0.0001185071,0.000001065104,0.00005480797],"genre_scores_gemma":[0.9995678,0.00004208214,0.00006186996,0.00000742762,0.000004768511,0.00001072921,0.0002576521,0.000002134877,0.00004553424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227431,"threshold_uncertainty_score":0.003445923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00901172426914697,"score_gpt":0.2194360652995583,"score_spread":0.2104243410304114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}