{"id":"W2347100538","doi":"10.1038/srep25602","title":"miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China","keywords":"Macrophage polarization; Angiogenesis; Prostate cancer; microRNA; Cancer research; Macrophage; M2 Macrophage; Phenotype; Prostate; Tumor necrosis factor alpha; Tumor microenvironment; Biology; Medicine; Immunology; Cancer; Internal medicine; In vitro; Gene; Genetics; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001183489,0.0002010022,0.0002877125,0.0001925375,0.000276919,0.00009113836,0.0001041342,0.0001120468,0.0002106451],"category_scores_gemma":[0.0002436455,0.000148551,0.00003919546,0.0004329969,0.0005328175,0.0002147858,0.0001699816,0.00008977049,0.00002123384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001353176,"about_ca_system_score_gemma":0.0001044222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005420117,"about_ca_topic_score_gemma":0.0003856626,"domain_scores_codex":[0.9978762,0.0001396829,0.0004932898,0.0009321406,0.00008759609,0.0004711166],"domain_scores_gemma":[0.9990563,0.00004707758,0.0002642953,0.0004359815,0.0001511052,0.00004524984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000380356,0.00007336136,0.1014497,0.0000242782,0.00003301056,0.0000719295,0.0006133012,0.000004067795,0.8842643,0.00000201481,0.0003855535,0.0130405],"study_design_scores_gemma":[0.00037001,0.00004686892,0.1470113,0.0001453522,0.00001804023,0.00007417385,0.00003905319,0.000003179993,0.8474022,0.0005470524,0.004139948,0.0002028979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871744,0.008489928,0.00001253885,0.0002837749,0.003221283,0.0006949341,0.00003924574,0.00005438673,0.00002954508],"genre_scores_gemma":[0.9902694,0.0001040163,0.00007654747,0.0000383194,0.00001043616,0.000102396,0.00002480299,0.00001967833,0.00935443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0455616,"threshold_uncertainty_score":0.6057734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005982565889323352,"score_gpt":0.2342681197338303,"score_spread":0.2282855538445069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}