{"id":"W2347100538","doi":"10.1038/srep25602","title":"miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Natural Science Foundation of China","keywords":"Macrophage polarization; Angiogenesis; Prostate cancer; microRNA; Cancer research; Macrophage; M2 Macrophage; Phenotype; Prostate; Tumor necrosis factor alpha; Tumor microenvironment; Biology; Medicine; Immunology; Cancer; Internal medicine; In vitro; Gene; Genetics; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674794,0.000180626,0.0003220645,0.0003049004,0.000218443,0.0003195821,0.0001434988,0.0002323332,0.001189065],"category_scores_gemma":[0.000160131,0.0001651716,0.0002911107,0.0001780352,0.0002249123,0.0001485909,0.0001752842,0.0006583181,0.0003563697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001676142,"about_ca_system_score_gemma":0.0003249342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935418,"about_ca_topic_score_gemma":0.0005009011,"domain_scores_codex":[0.999855,0.0000431675,0.000009271052,0.00001272701,0.00004318792,0.00003655467],"domain_scores_gemma":[0.9999359,0.000008218357,0.0000114599,0.000005316899,0.00001331662,0.00002580226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005112527,0.0001193419,0.0008326955,0.00009299293,0.00001728407,0.00009398364,0.00003900185,0.00006931076,0.9934826,0.0001139407,0.0001851076,0.004442372],"study_design_scores_gemma":[0.0001221614,0.002095392,0.03170463,0.00002131602,0.0001257302,0.0009400529,0.0001981349,0.0013495,0.9543046,0.0002666609,0.00885154,0.00002034542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855985,0.01061201,0.001334691,0.0003038588,0.0001233846,0.00002872761,0.0001131687,0.00009698407,0.001788714],"genre_scores_gemma":[0.9953191,0.002548406,0.0006400509,0.000134959,0.00002181252,0.00002563372,0.000127381,0.00001381611,0.001168844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189065,"threshold_uncertainty_score":0.003977776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005982565889323352,"score_gpt":0.2342681197338303,"score_spread":0.2282855538445069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}