{"id":"W2347120526","doi":"10.1210/en.2016-1085","title":"Membrane-Localized Estrogen Receptor 1 Is Required for Normal Male Reproductive Development and Function in Mice","year":2016,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Veterans Affairs; National Institute of Child Health and Human Development; National Institutes of Health; University of Virginia","keywords":"Estrogen receptor alpha; Epididymis; Endocrinology; Estrogen receptor; Internal medicine; Biology; Spermatogenesis; Estrogen; Sperm; Efferent ducts; Efferent; Andrology; Nuclear receptor; Estrogen receptor beta; Medicine; Genetics; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004290048,0.0007579961,0.000556612,0.001127488,0.0003895728,0.0006915517,0.0007064423,0.0009717905,0.005914825],"category_scores_gemma":[0.0003793169,0.0006374983,0.0005713862,0.000252871,0.0006953832,0.0005081156,0.0006446178,0.001297842,0.002036916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005469134,"about_ca_system_score_gemma":0.0003657246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006236171,"about_ca_topic_score_gemma":0.0009096807,"domain_scores_codex":[0.999266,0.000115709,0.00009534097,0.000211617,0.0001734639,0.0001379729],"domain_scores_gemma":[0.9991747,0.00006014996,0.0003587181,0.0001146827,0.00005906193,0.0002326789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003969672,0.00008873951,0.0006093626,0.00006900872,0.00001930867,0.0003493862,0.00004474427,0.00009129109,0.9946748,0.000431242,0.000207416,0.003017684],"study_design_scores_gemma":[0.0003183064,0.001124142,0.03306847,0.0001061202,0.000130351,0.00399233,0.0001843793,0.001574322,0.9245226,0.0007637705,0.03416656,0.00004871566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712261,0.004095885,0.01109222,0.0008542758,0.0002008855,0.0001513554,0.005317866,0.001171309,0.005890191],"genre_scores_gemma":[0.9658229,0.002646111,0.006792286,0.0003780062,0.0000827802,0.0003001858,0.00317435,0.0004419038,0.02036144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005914825,"threshold_uncertainty_score":0.01978707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017343016676692,"score_gpt":0.2362355445718043,"score_spread":0.2260621144050374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}