{"id":"W2347124890","doi":"10.1042/cs20160084","title":"The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease","year":2016,"lang":"en","type":"review","venue":"Clinical Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"HDAC6; Disease; Malignancy; Neurodegeneration; Biology; Histone deacetylase; Proteasome; Cancer research; Medicine; Histone; Cell biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002926722,0.0002303103,0.0004767556,0.00006893834,0.0003078791,0.00008785305,0.0008761483,0.0002333625,0.000004181981],"category_scores_gemma":[0.002125579,0.0001231058,0.0003064866,0.0003088446,0.002481275,0.00000685081,0.0004419439,0.0002457323,0.00002926166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001154182,"about_ca_system_score_gemma":0.002455441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002379054,"about_ca_topic_score_gemma":0.00002245001,"domain_scores_codex":[0.9972971,0.0002426465,0.0006834081,0.0009041408,0.0002857659,0.0005869014],"domain_scores_gemma":[0.9981474,0.0005434731,0.0001891519,0.0007015704,0.00009339222,0.0003249618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001712532,0.00003043237,0.00002263231,0.0004479098,0.000008913642,0.000002794978,0.000001482763,6.100817e-8,0.0001704585,0.0001209455,0.0006935485,0.9984837],"study_design_scores_gemma":[0.0002358234,0.0002179966,0.00003775681,0.001980586,0.00002389953,0.000002904945,0.000001332406,0.000006865952,0.00009253919,0.00009048346,0.9971132,0.000196638],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006228095,0.9974141,0.00003900574,0.000257558,0.000490586,0.001026565,0.00003649919,0.000005552105,0.0001073902],"genre_scores_gemma":[0.001270694,0.9965081,0.00001976988,0.0000442114,0.0007637891,0.0002742017,0.00001144251,0.00002682708,0.00108092],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9982871,"threshold_uncertainty_score":0.9142359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07270271671695265,"score_gpt":0.4596861647569606,"score_spread":0.3869834480400079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}