{"id":"W2347124890","doi":"10.1042/cs20160084","title":"The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease","year":2016,"lang":"en","type":"review","venue":"Clinical Science","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"HDAC6; Disease; Malignancy; Neurodegeneration; Biology; Histone deacetylase; Proteasome; Cancer research; Medicine; Histone; Cell biology; Genetics; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008896294,0.0006110563,0.000736063,0.0007843011,0.000374786,0.001149164,0.000484951,0.001632068,0.004358153],"category_scores_gemma":[0.0007607946,0.0001795115,0.0004653874,0.0005497083,0.0008292155,0.001635951,0.0007038192,0.003955801,0.002328025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000718701,"about_ca_system_score_gemma":0.0006502632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003315718,"about_ca_topic_score_gemma":0.001318944,"domain_scores_codex":[0.9997594,0.00006591565,0.0000236036,0.00004166631,0.00007132566,0.00003819397],"domain_scores_gemma":[0.9996632,0.0001150471,0.00004677389,0.00001586952,0.00008461833,0.00007450704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007047491,0.000291197,0.0007466592,0.004151346,0.0001067551,0.0009838199,0.0002239337,0.0005365344,0.02493766,0.03196526,0.1244231,0.810929],"study_design_scores_gemma":[0.0001012745,0.0005610844,0.0007320881,0.0006019592,0.00005627867,0.001638639,0.00006961568,0.0001504026,0.0024338,0.009062239,0.9845693,0.00002339534],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001672553,0.9693267,0.001681049,0.01872267,0.002700555,0.00002309438,0.00007892964,0.00008095959,0.005713325],"genre_scores_gemma":[0.01288852,0.9597434,0.003152276,0.01004321,0.004654432,0.00004655457,0.000174496,0.00003018788,0.009266831],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004358153,"threshold_uncertainty_score":0.01457942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07270271671695265,"score_gpt":0.4596861647569606,"score_spread":0.3869834480400079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}