{"id":"W2347182223","doi":"10.1681/asn.2015070734","title":"Double Knockout of the Na+-Driven Cl−/HCO3 − Exchanger and Na+/Cl− Cotransporter Induces Hypokalemia and Volume Depletion","year":2016,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Agence Nationale de la Recherche","keywords":"Cotransporter; Pendrin; Knockout mouse; Chemistry; Endocrinology; Internal medicine; Aldosterone; Epithelial sodium channel; Homeostasis; Hypokalemia; Renin–angiotensin system; Sodium–hydrogen antiporter; Amiloride; Symporter; Sodium; Biology; Biochemistry; Transporter; Medicine; Blood pressure; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001750436,0.0001020207,0.0002470009,0.00001761228,0.00006068846,0.000003177509,0.0001803222,0.0001085933,0.00001071091],"category_scores_gemma":[0.000004772358,0.00005384035,0.0002306448,0.00007569513,0.0008439861,0.000009723545,0.00004405465,0.00009670239,1.531817e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009739245,"about_ca_system_score_gemma":0.00004934776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002407125,"about_ca_topic_score_gemma":0.00001486917,"domain_scores_codex":[0.9992556,0.00005722902,0.000293423,0.000119958,0.0001419441,0.0001318519],"domain_scores_gemma":[0.9989637,0.00001591099,0.0006845149,0.0001638508,0.0001329255,0.00003917169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000265352,0.00002387358,0.03776926,0.00001643329,0.0001269436,2.518285e-7,0.0003380097,0.000009335265,0.9566715,0.000006991183,0.002046223,0.002725838],"study_design_scores_gemma":[0.00172564,0.0007009467,0.7747255,0.00005542488,0.0001558373,0.0001064547,0.0004215143,0.00002851872,0.2053483,0.0001310823,0.01646775,0.0001330468],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950628,0.0003621182,0.0006903275,0.00368559,0.00009112826,0.00008350959,0.00001181547,0.000001452915,0.00001122346],"genre_scores_gemma":[0.9976857,0.00081965,0.0002794992,0.0008459236,0.000170335,0.000001628122,0.000001956906,0.00001019926,0.0001850724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7513232,"threshold_uncertainty_score":0.3109702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112578948899114,"score_gpt":0.2303451615103935,"score_spread":0.2190872666204821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}