{"id":"W2347920624","doi":"10.1038/srep24480","title":"The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; START Clinic; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Synarc; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Posterior cingulate; Genome-wide association study; Alzheimer's Disease Neuroimaging Initiative; Population; Cingulate cortex; Neuroimaging; Neuroscience; Medicine; Biology; Alzheimer's disease; Internal medicine; Disease; Genetics; Cognition; Genotype; Central nervous system; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003246914,0.0005276142,0.0003180575,0.0007691804,0.0004143282,0.0005256838,0.0003307913,0.0005026653,0.00276013],"category_scores_gemma":[0.001524235,0.0001884985,0.0005442073,0.0006560717,0.0003635866,0.0002634241,0.0004415424,0.0005108497,0.0001831438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158572,"about_ca_system_score_gemma":0.0001497387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004099078,"about_ca_topic_score_gemma":0.004989643,"domain_scores_codex":[0.999674,0.00007121408,0.00003337094,0.0001422443,0.00003926759,0.00003986368],"domain_scores_gemma":[0.9995147,0.0001744857,0.0001530994,0.00006215781,0.00003801131,0.0000575501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004114982,0.000140231,0.9186537,0.0001297802,0.001744105,0.003167131,0.0008630416,0.0008896337,0.04808131,0.00113091,0.001011125,0.02007402],"study_design_scores_gemma":[0.00002748713,0.00007789152,0.9943439,0.00002050649,0.0003560815,0.001137047,0.0001272484,0.001168973,0.001468669,0.0006733458,0.0005850925,0.00001377759],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982207,0.0003905958,0.0004488355,0.00008643625,0.00001268367,0.000006129572,0.0003488102,0.0000124461,0.0004732611],"genre_scores_gemma":[0.9991731,0.00007385877,0.0003408793,0.00003176581,0.0000105425,0.000005516355,0.0001682857,0.000009660761,0.0001862993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004099078,"threshold_uncertainty_score":0.009233594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379434128299543,"score_gpt":0.3324538888292636,"score_spread":0.2986595475462682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}