{"id":"W2350006663","doi":"","title":"Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"High-throughput screening; Recombinant DNA; Chemistry; Elastase; Biochemistry; Enzyme; In vitro; Escherichia coli; Inclusion bodies; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006879711,0.0004458976,0.0004154869,0.0002775982,0.0001578704,0.0002724353,0.0002844439,0.000307563,0.0007665082],"category_scores_gemma":[0.0004080491,0.0001627412,0.0003315927,0.0003104811,0.0001477746,0.0001840166,0.0002123291,0.0004769387,0.0005885291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003569703,"about_ca_system_score_gemma":0.0002720731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004894469,"about_ca_topic_score_gemma":0.0009614945,"domain_scores_codex":[0.9996663,0.00009047955,0.00003498976,0.00004311225,0.0001314842,0.00003362542],"domain_scores_gemma":[0.9998407,0.00004325803,0.00003014655,0.00002854101,0.0000362208,0.00002103637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004802748,0.0000409209,0.0002081211,0.000093529,0.000009237155,0.00003855997,0.000006399464,0.0001248408,0.9961099,0.00004989608,0.00009096431,0.003179619],"study_design_scores_gemma":[0.00002034964,0.0001554757,0.0015244,0.000007653857,0.00002278652,0.0004349849,0.000006863203,0.0007211686,0.9921321,0.00002623536,0.004944297,0.000003621672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8229967,0.02134291,0.145938,0.0006784036,0.0001084438,0.0008396301,0.004480469,0.0004334154,0.0031821],"genre_scores_gemma":[0.8063006,0.008786891,0.1659731,0.000246058,0.00004419064,0.0004211606,0.01250052,0.00006728686,0.005660192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007665082,"threshold_uncertainty_score":0.003638387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02766950632926691,"score_gpt":0.2674165570033195,"score_spread":0.2397470506740526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}