{"id":"W2350006663","doi":"","title":"Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening.","year":2002,"lang":"en","type":"article","venue":"PubMed","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"High-throughput screening; Recombinant DNA; Chemistry; Elastase; Biochemistry; Enzyme; In vitro; Escherichia coli; Inclusion bodies; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291406,0.00007363857,0.000114201,0.00004559581,0.00004498936,0.000006163312,0.00009430713,0.00007048043,0.00001156949],"category_scores_gemma":[0.0001727471,0.00007216518,0.0000360313,0.00005407892,0.0001115752,0.000004391372,0.00007649043,0.00003485768,4.084095e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006133058,"about_ca_system_score_gemma":0.000004382601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002549953,"about_ca_topic_score_gemma":0.00001083415,"domain_scores_codex":[0.9992571,0.00003810692,0.0001641257,0.0002695328,0.0001021175,0.0001689936],"domain_scores_gemma":[0.9994677,0.00002122173,0.00008765262,0.0002853403,0.00008917351,0.00004894361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008997415,0.0001029531,0.0009579409,0.00009431166,0.0000233404,4.714195e-7,0.00008636371,0.000001726126,0.9528329,0.0001259567,0.0009211637,0.04476288],"study_design_scores_gemma":[0.001060647,0.0001373542,0.02254108,0.000007754857,0.000008395467,0.000001095899,0.00008657411,0.00001307409,0.974793,0.0002086855,0.001064352,0.00007799469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955935,0.001369194,0.001909609,0.00009980812,0.00001815421,0.0007395413,0.00007724224,0.000003738529,0.0001892075],"genre_scores_gemma":[0.9983736,0.00004713207,0.0006280691,0.000007405336,0.00004774532,0.0004259828,0.0000979601,0.00001348993,0.000358591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04468488,"threshold_uncertainty_score":0.2942811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02766950632926691,"score_gpt":0.2674165570033195,"score_spread":0.2397470506740526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}