{"id":"W2350561728","doi":"10.1016/j.antiviral.2016.05.006","title":"The E119D neuraminidase mutation identified in a multidrug-resistant influenza A(H1N1)pdm09 isolate severely alters viral fitness in vitro and in animal models","year":2016,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Zanamivir; Oseltamivir; Neuraminidase; Virology; Titer; Biology; Virus; Microbiology; Resistance mutation; Medicine; RNA; Reverse transcriptase; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00428603,0.0002798371,0.000488968,0.001102261,0.0002781672,0.0001548338,0.0003261522,0.0001600185,0.000003953829],"category_scores_gemma":[0.002731853,0.0001766116,0.00007295154,0.001137548,0.0009383212,0.0008650278,0.0005227718,0.001041328,0.00005384978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004766267,"about_ca_system_score_gemma":0.0003132149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002627259,"about_ca_topic_score_gemma":0.002789572,"domain_scores_codex":[0.9947703,0.001003682,0.0007420139,0.0007057158,0.001320314,0.001457929],"domain_scores_gemma":[0.9970556,0.001943316,0.0000801787,0.0004675974,0.0003258108,0.000127532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03248166,0.0003543363,0.03070169,0.0002343836,0.00006212381,0.00212605,0.002959512,0.00002674651,0.9023242,0.0004813277,0.0001449936,0.02810298],"study_design_scores_gemma":[0.01560481,0.0009131587,0.8415733,0.001083618,0.00001420019,0.00002180729,0.00206854,0.03360177,0.1010177,0.003296466,0.00029282,0.0005117872],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951627,0.0007764378,0.00001372342,0.00208896,0.00003921292,0.001345799,0.00003310553,0.00002597151,0.0005140657],"genre_scores_gemma":[0.9982627,0.0007075059,0.0000572912,0.0001502511,0.00004378516,0.0002247459,0.000004221044,0.00004166873,0.0005078126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8108716,"threshold_uncertainty_score":0.7202011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1426097270306932,"score_gpt":0.4341535866068056,"score_spread":0.2915438595761124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}