{"id":"W2350756401","doi":"10.1021/acs.orglett.6b01222","title":"Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators","year":2016,"lang":"en","type":"article","venue":"Organic Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Government of Canada; Children's Hospital Foundation; Alberta Children's Hospital Research Institute; Movember Foundation; Prostate Cancer Canada; University of Calgary","keywords":"Transient receptor potential channel; Chemistry; TRPM8; Transient (computer programming); Natural product; Channel (broadcasting); Receptor; Biochemistry; Telecommunications; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001452349,0.000321101,0.0002579773,0.0001386479,0.0002578257,0.00005592233,0.0004288311,0.00007634985,0.001262565],"category_scores_gemma":[0.000199145,0.0002073395,0.00015455,0.000370867,0.0002287289,0.0003167854,0.00008087233,0.0002157386,0.000966312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304225,"about_ca_system_score_gemma":0.0000398515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008416889,"about_ca_topic_score_gemma":0.000001807342,"domain_scores_codex":[0.9974925,0.0001581981,0.0003343364,0.0008476212,0.000501005,0.0006663273],"domain_scores_gemma":[0.9992778,0.00007671979,0.0001341263,0.0002871351,0.00003875915,0.0001854598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003631155,0.00004767393,0.000002038772,0.000009777448,0.00001073016,0.00001683782,0.0005726321,0.00002256395,0.9843397,0.00002980682,0.01279636,0.00211553],"study_design_scores_gemma":[0.0008577341,0.00004876042,0.00007270592,0.00003320758,0.00001203809,0.0000322853,0.0000618663,0.00008404812,0.9962249,0.00002793043,0.002175318,0.0003692063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952399,0.00003294957,0.003043605,0.03771055,0.006232239,0.0003034883,0.0000284941,0.0002211282,0.0000285421],"genre_scores_gemma":[0.9945354,0.00008055615,0.0001136202,0.00376526,0.0007660838,0.00001438889,0.000004057372,0.0000782465,0.0006423478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04213643,"threshold_uncertainty_score":0.9998115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143958919457266,"score_gpt":0.2067194218762355,"score_spread":0.1952798326816628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}