{"id":"W2350756401","doi":"10.1021/acs.orglett.6b01222","title":"Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators","year":2016,"lang":"en","type":"article","venue":"Organic Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Children's Hospital Foundation; Government of Canada; Children's Hospital Foundation; Alberta Children's Hospital Research Institute; Movember Foundation; Prostate Cancer Canada; University of Calgary","keywords":"Transient receptor potential channel; Chemistry; TRPM8; Transient (computer programming); Natural product; Channel (broadcasting); Receptor; Biochemistry; Telecommunications; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001084113,0.0003732739,0.0003681586,0.0003106893,0.0001410668,0.0002141833,0.000328228,0.0002037554,0.002284272],"category_scores_gemma":[0.0001844046,0.0001024422,0.0002176278,0.0003041046,0.0001623884,0.000249992,0.000226476,0.000419943,0.0004604915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002575351,"about_ca_system_score_gemma":0.0001608469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002128439,"about_ca_topic_score_gemma":0.0007136814,"domain_scores_codex":[0.9999425,0.00000945938,0.000005255146,0.00001266481,0.00001742608,0.00001264933],"domain_scores_gemma":[0.9999315,0.00001679767,0.0000144057,0.000009892524,0.00001281399,0.00001463829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003794764,0.0001303548,0.0002857981,0.0001310557,0.00002349511,0.0002129934,0.00004192616,0.0007221329,0.9878435,0.0003527654,0.0001433817,0.00973302],"study_design_scores_gemma":[0.0001362109,0.002735343,0.002430309,0.00001683382,0.00009397673,0.0007396624,0.00004830703,0.0007859051,0.9813792,0.0001263495,0.01148766,0.00002032926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842888,0.003432909,0.00553239,0.0001937905,0.00003223302,0.0002199671,0.001144669,0.0001651624,0.004990073],"genre_scores_gemma":[0.9867938,0.003170411,0.006057372,0.00008774138,0.00001990656,0.0001051715,0.001126874,0.00002125613,0.002617502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002284272,"threshold_uncertainty_score":0.007641613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01143958919457266,"score_gpt":0.2067194218762355,"score_spread":0.1952798326816628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}