{"id":"W2350852627","doi":"","title":"The anxiolytic effect and mechanism of indole derivate I_(20)","year":2002,"lang":"en","type":"article","venue":"","topic":"Organic Chemistry Cycloaddition Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CAE (Canada)","funders":"","keywords":"Neuroactive steroid; Anxiolytic; Elevated plus maze; GABAA receptor; Benzodiazepine; Pharmacology; Chemistry; Receptor; Internal medicine; Open field; Sedation; Mechanism of action; Endocrinology; Medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006150948,0.0001045774,0.0001134716,0.000009932689,0.0001286056,0.00002481521,0.0001136838,0.00007723237,0.006788632],"category_scores_gemma":[0.00009380532,0.00007369669,0.00004310692,0.00006884605,0.00007546566,0.00004023455,0.00005260779,0.0001222611,0.00005469003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002613941,"about_ca_system_score_gemma":0.000006190457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008156107,"about_ca_topic_score_gemma":0.000004134049,"domain_scores_codex":[0.9994184,0.000008742707,0.0001571923,0.0001477617,0.0001216754,0.0001462615],"domain_scores_gemma":[0.9992954,0.0002773094,0.00006924793,0.0002755571,0.00002140772,0.00006109717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003805432,0.00002431878,0.0001073897,0.00004978165,0.00003003751,0.000001883172,0.00002669411,2.260874e-7,0.9942529,0.0007796488,0.002327794,0.002395513],"study_design_scores_gemma":[0.0003668712,0.00001141689,0.00003269372,0.00001575624,0.00002160179,0.00004356877,0.00006704608,0.0003799627,0.989594,0.0004510739,0.008930851,0.000085197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8206254,0.000169801,0.00005964245,0.0005176637,0.00005225699,0.00006635685,0.00002974379,0.0001182468,0.1783609],"genre_scores_gemma":[0.9882852,0.0001015512,0.00004446805,0.00002671838,0.00005192976,0.00001319707,0.000005621212,0.00001351287,0.0114578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1676598,"threshold_uncertainty_score":0.9941193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005397843392810366,"score_gpt":0.1905157773175324,"score_spread":0.185117933924722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}