{"id":"W2352795241","doi":"10.1182/blood.v122.21.130.130","title":"A Transgenic Model Of Multiple Myeloma Bone Disease Shows Profound Mesenchymal Stem Cell Impairment","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Genetically modified mouse; Apposition; Osteoclast; Transgene; Bone disease; Mesenchymal stem cell; Pathology; Osteolysis; Multiple myeloma; Osteoblast; Bone mineral; Biology; Immunology; Internal medicine; Osteoporosis; Medicine; Anatomy; Surgery; In vitro; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001922702,0.000567821,0.0004225528,0.0007909125,0.0002940524,0.0004162861,0.0003367293,0.0008828393,0.003527333],"category_scores_gemma":[0.0001160144,0.0002731914,0.0004858618,0.0004311134,0.0003764928,0.0002111823,0.0002751912,0.001346046,0.0008852889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004524198,"about_ca_system_score_gemma":0.0002498309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001583243,"about_ca_topic_score_gemma":0.001621263,"domain_scores_codex":[0.9994838,0.00003685896,0.00005677587,0.0000993417,0.0002305894,0.00009256697],"domain_scores_gemma":[0.9996994,0.00003086695,0.00009886009,0.00003058678,0.0000302759,0.0001100752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001059823,0.00006717642,0.0001635487,0.00002378081,0.000006161966,0.0001439277,0.00001545021,0.00005220835,0.9986176,0.0001377202,0.0001032404,0.0005631829],"study_design_scores_gemma":[0.00007970038,0.001249339,0.007529836,0.00001383549,0.00004735557,0.001941348,0.00008307271,0.001399522,0.980745,0.0002145816,0.006679271,0.00001715773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856904,0.001200671,0.005718584,0.0004754705,0.0001403947,0.00009742307,0.00337739,0.0004794778,0.002820249],"genre_scores_gemma":[0.9819708,0.0008116679,0.004286399,0.0001972919,0.00003309879,0.000140893,0.002624547,0.00008081061,0.009854422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003527333,"threshold_uncertainty_score":0.01180011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733074551796692,"score_gpt":0.261344525959862,"score_spread":0.234013780441895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}