{"id":"W2352888873","doi":"10.1002/hep.28637","title":"Hepatocellular carcinoma repression by TNFα‐mediated synergistic lethal effect of mitosis defect‐induced senescence and cell death sensitization","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of Science and Technology of China; Science and Technology Commission of Shanghai Municipality; Directorate for Biological Sciences; Chinese Academy of Sciences; China Postdoctoral Science Foundation; National Natural Science Foundation of China; National Institutes of Health; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; National Science Foundation","keywords":"Survivin; HCCS; Mitotic catastrophe; Cancer research; Senescence; Programmed cell death; Apoptosis; Mitosis; Medicine; Tumor necrosis factor alpha; Biology; Hepatocellular carcinoma; Cancer; Immunology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001129835,0.0003791064,0.0002082743,0.0001780333,0.0001057279,0.000182428,0.0001235098,0.0001380633,0.001131957],"category_scores_gemma":[0.00006264941,0.00007940164,0.0002303189,0.0001158232,0.0001844791,0.000141893,0.0001783092,0.0003519494,0.0003248865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002322646,"about_ca_system_score_gemma":0.0002244388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002106654,"about_ca_topic_score_gemma":0.0002913748,"domain_scores_codex":[0.9999193,0.00001459256,0.00001053042,0.00001526047,0.0000199816,0.00002038072],"domain_scores_gemma":[0.9999274,0.000007581562,0.00003094754,0.00001052859,0.000008165928,0.00001526545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198515,0.00003513332,0.0002652195,0.00004651506,0.000005211708,0.00005272818,0.00000797858,0.00005898156,0.9972063,0.0001014523,0.00003716906,0.002063399],"study_design_scores_gemma":[0.00002380569,0.0005673242,0.002687988,0.000005657292,0.00002006402,0.0004392131,0.00001422848,0.000543386,0.9934831,0.00003640189,0.00217586,0.000002900871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857813,0.005636539,0.005276808,0.0001435392,0.0000618493,0.000053285,0.0002143604,0.0001640345,0.002668371],"genre_scores_gemma":[0.9958235,0.001298477,0.001394013,0.00003190093,0.0000107461,0.00002846738,0.0001857293,0.000009166043,0.001217998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001131957,"threshold_uncertainty_score":0.003786743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005879545392324883,"score_gpt":0.2075323487547469,"score_spread":0.201652803362422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}