{"id":"W2352888873","doi":"10.1002/hep.28637","title":"Hepatocellular carcinoma repression by TNFα‐mediated synergistic lethal effect of mitosis defect‐induced senescence and cell death sensitization","year":2016,"lang":"en","type":"article","venue":"Hepatology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of Science and Technology of China; Science and Technology Commission of Shanghai Municipality; Directorate for Biological Sciences; Chinese Academy of Sciences; China Postdoctoral Science Foundation; National Natural Science Foundation of China; National Institutes of Health; Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; National Science Foundation","keywords":"Survivin; HCCS; Mitotic catastrophe; Cancer research; Senescence; Programmed cell death; Apoptosis; Mitosis; Medicine; Tumor necrosis factor alpha; Biology; Hepatocellular carcinoma; Cancer; Immunology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635133,0.0001836316,0.0002586815,0.00005084097,0.00006271905,0.000005162552,0.00006908402,0.0003310461,0.00001418831],"category_scores_gemma":[0.0001239308,0.00012943,0.00007909284,0.0000616169,0.00006699199,0.000004509568,0.00008139796,0.00004610494,0.000004673911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000133886,"about_ca_system_score_gemma":0.0000294078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008382982,"about_ca_topic_score_gemma":0.000005186484,"domain_scores_codex":[0.9987408,0.0002569853,0.0002351174,0.0004446459,0.00009997761,0.0002224945],"domain_scores_gemma":[0.9992907,0.0001103005,0.000151716,0.0002954377,0.00006747427,0.00008439145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001021577,0.00001897462,0.2180813,0.0000564231,0.00001303887,0.00001074865,0.000008297169,7.033385e-7,0.7806048,0.00003113504,0.00009306569,0.0009793144],"study_design_scores_gemma":[0.0009348165,0.0005166312,0.003990702,0.00002948573,0.00005703216,0.00004726712,0.0000022509,0.002055279,0.9919778,0.00004266407,0.0001800448,0.0001660893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921016,0.0007834601,0.006543179,0.000074672,0.000153863,0.0002205666,0.00002007977,0.00001294875,0.00008959255],"genre_scores_gemma":[0.9991481,0.000281542,0.0001472225,0.00002416467,0.00005470492,0.00001432946,0.0001468148,0.00002366269,0.0001594466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2140906,"threshold_uncertainty_score":0.5278001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005879545392324883,"score_gpt":0.2075323487547469,"score_spread":0.201652803362422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}