{"id":"W2355988234","doi":"10.1016/j.cjca.2015.07.320","title":"NRF2 PROTECTS AGAINST ISCHEMIA REPERFUSION INJURY VIA INHIBITION OF NF-κB ACTIVATION AND SUPPRESSES SUBSEQUENT DEVELOPMENT OF CARDIAC ALLOGRAFT VASCULOPATHY IN MURINE HEART TRANSPLANTATION","year":2015,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Medicine; Oxidative stress; Transplantation; Reperfusion injury; Inflammation; Heart transplantation; SOD2; Ischemia; Knockout mouse; Pharmacology; Apoptosis; Superoxide dismutase; Cardiac function curve; Immunology; Internal medicine; Endocrinology; Receptor; Heart failure; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003359878,0.0005137075,0.0005331541,0.0004826944,0.0002650402,0.0002990901,0.0002677609,0.0004199707,0.001809564],"category_scores_gemma":[0.0001581819,0.0002328309,0.0003500788,0.000202623,0.0005194417,0.0004435329,0.0001847136,0.001060988,0.0003248255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002395815,"about_ca_system_score_gemma":0.0004137205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005530231,"about_ca_topic_score_gemma":0.001650351,"domain_scores_codex":[0.9998338,0.00003011284,0.00001564873,0.00002927088,0.00003426057,0.00005697967],"domain_scores_gemma":[0.9998228,0.00001122125,0.00004687017,0.00002423709,0.00001784927,0.00007706897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001520554,0.0004097293,0.0001982194,0.00007104644,0.00001717205,0.00006674958,0.00003259149,0.00006848008,0.9953556,0.0001846699,0.000136925,0.001938233],"study_design_scores_gemma":[0.0002596974,0.002240374,0.004738144,0.00002402697,0.00007542571,0.0002409044,0.0001141088,0.0008420696,0.9887793,0.0002285218,0.002440318,0.00001705503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941196,0.00169367,0.002294624,0.0003510161,0.0001073236,0.00003686569,0.000289582,0.0001742193,0.0009330627],"genre_scores_gemma":[0.994365,0.0008526266,0.001099281,0.00008909374,0.00002396323,0.00005358326,0.0002784616,0.00002783269,0.003210187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001809564,"threshold_uncertainty_score":0.006053627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01153530662000068,"score_gpt":0.2226010296514599,"score_spread":0.2110657230314592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}