{"id":"W2356803257","doi":"10.1158/2326-6066.cir-15-0302","title":"Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy","year":2016,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Queen's University Belfast; Queen's University; Cancer Research UK","keywords":"Colorectal cancer; Immune system; Adjuvant; Medicine; Stage (stratigraphy); Chemotherapy; Oncology; Immunotherapy; Cancer; Immunology; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783811,0.0001826673,0.0003633373,0.0004370923,0.0002349572,0.0004613468,0.0001294835,0.0002895587,0.001088506],"category_scores_gemma":[0.0005346626,0.0001065675,0.0003518667,0.0002776172,0.0002280224,0.0001539216,0.0002148445,0.0003435141,0.0002489029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001582505,"about_ca_system_score_gemma":0.0001438648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009611908,"about_ca_topic_score_gemma":0.001159411,"domain_scores_codex":[0.9998897,0.00002807509,0.000007789067,0.00003073299,0.00001393874,0.00002972416],"domain_scores_gemma":[0.9996837,0.00005781918,0.0001237424,0.00002590242,0.00001947916,0.00008938538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001011302,0.00002977613,0.9859784,0.000009625591,0.00004066082,0.0002065975,0.00003917225,0.0001236467,0.008185565,0.00003656099,0.00009761422,0.004241147],"study_design_scores_gemma":[0.0000171499,0.0002434643,0.9972917,0.000003099104,0.00003969673,0.0007206842,0.0000880016,0.0006628518,0.0005274751,0.0001011504,0.000300932,0.000003822663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993691,0.0001535001,0.0001155475,0.00002858059,0.000002330622,0.00000402781,0.00006271103,0.000004142778,0.0002600173],"genre_scores_gemma":[0.9996805,0.00003128315,0.00005262261,0.0000235682,0.000003968136,0.000002357473,0.0001182578,0.000001714076,0.00008577876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088506,"threshold_uncertainty_score":0.003641367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03448511688458177,"score_gpt":0.3306681204005528,"score_spread":0.296183003515971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}