{"id":"W2358862840","doi":"10.1093/annonc/mdu349.74","title":"Efficacy and Safety of Ceritinib in Patients (Pts) with Advanced Anaplastic Lymphoma Kinase (Alk)-Rearranged (Alk+) Non-Small Cell Lung Cancer (Nsclc): an Update of Ascend-1","year":2014,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Ceritinib; Anaplastic lymphoma kinase; Medicine; Crizotinib; Lung cancer; ALK inhibitor; Alectinib; Anaplastic large-cell lymphoma; Cancer research; Lymphoma; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002698264,0.0004819019,0.0028697,0.0006544009,0.0002028566,0.001004439,0.000755896,0.000536577,0.001051029],"category_scores_gemma":[0.003319063,0.0001977446,0.001717453,0.0007621261,0.0003373888,0.001089987,0.0003070816,0.001597896,0.0003510835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00124408,"about_ca_system_score_gemma":0.0006604245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008177018,"about_ca_topic_score_gemma":0.003424274,"domain_scores_codex":[0.9993394,0.0001420887,0.0001412701,0.0001049434,0.0002097777,0.0000624427],"domain_scores_gemma":[0.997705,0.001118824,0.0006129489,0.00007552886,0.0003486635,0.0001389098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01579976,0.0003295563,0.04471615,0.004375246,0.002689882,0.0002716914,0.0001235877,0.00161258,0.004261293,0.0003597034,0.01686684,0.9085937],"study_design_scores_gemma":[0.01936458,0.03787493,0.6085707,0.003876956,0.02417061,0.01127355,0.0003356605,0.003916982,0.01222019,0.002280019,0.2757709,0.0003448721],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2712167,0.704565,0.001074915,0.004999509,0.0006818858,0.0001902525,0.004062873,0.000255855,0.01295304],"genre_scores_gemma":[0.7567159,0.2225899,0.00203464,0.004734307,0.001834259,0.0001792485,0.009557914,0.0001265098,0.00222729],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0028697,"threshold_uncertainty_score":0.01426995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148154935152017,"score_gpt":0.3438995017246584,"score_spread":0.3290840082094567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}