{"id":"W2359677118","doi":"10.1093/toxsci/kfw088","title":"Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia","year":2016,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Canadian Institutes of Health Research; U.S. Environmental Protection Agency","keywords":"Spermatogenesis; Andrology; Stem cell; Biology; Epididymis; Germ cell; Sperm; Seminiferous tubule; Benzo(a)pyrene; Gamete; Molecular biology; Cell biology; Genetics; Internal medicine; Endocrinology; Sertoli cell; Carcinogen; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899569,0.0003395592,0.0002423643,0.0005708696,0.0001480508,0.000260208,0.0001318396,0.000279518,0.001572594],"category_scores_gemma":[0.00009622749,0.0003295889,0.0003786668,0.0003060948,0.0001729259,0.0001517976,0.0001755719,0.0004244003,0.0003710201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000152406,"about_ca_system_score_gemma":0.0002002132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008863397,"about_ca_topic_score_gemma":0.001270854,"domain_scores_codex":[0.9997451,0.00003878523,0.00002740934,0.00005925405,0.00009093939,0.00003850164],"domain_scores_gemma":[0.999791,0.0000230193,0.00007830918,0.00002312099,0.00003434347,0.00005026544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005759644,0.00001491026,0.0004318489,0.00001646464,0.000004195162,0.00001276642,0.00001019288,0.00001310356,0.9989514,0.00001279308,0.000008485588,0.0004661978],"study_design_scores_gemma":[0.00001469844,0.001077018,0.02441862,0.00000745336,0.00002535609,0.0001395738,0.00002693032,0.0001754591,0.9729276,0.00003326018,0.001149443,0.000004450104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933515,0.001869545,0.00253484,0.00004659475,0.00002112818,0.00005509731,0.0008376216,0.0001110918,0.001172592],"genre_scores_gemma":[0.9873626,0.001960103,0.002560548,0.00006698896,0.00001205606,0.00009069867,0.001441125,0.00003395959,0.006472027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572594,"threshold_uncertainty_score":0.005260825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0455286832289002,"score_gpt":0.2799173794948165,"score_spread":0.2343886962659164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}