{"id":"W2359677118","doi":"10.1093/toxsci/kfw088","title":"Benzo(a)pyrene Is Mutagenic in Mouse Spermatogonial Stem Cells and Dividing Spermatogonia","year":2016,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"Canadian Institutes of Health Research; U.S. Environmental Protection Agency","keywords":"Spermatogenesis; Andrology; Stem cell; Biology; Epididymis; Germ cell; Sperm; Seminiferous tubule; Benzo(a)pyrene; Gamete; Molecular biology; Cell biology; Genetics; Internal medicine; Endocrinology; Sertoli cell; Carcinogen; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004210254,0.0001394896,0.0002437634,0.0001044323,0.0001403263,0.00004644527,0.0001199176,0.0001186662,0.0008966243],"category_scores_gemma":[0.00007966399,0.00007204647,0.00005258617,0.000244868,0.0004469226,0.0001661755,0.00009573714,0.00009515291,0.0001271273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006628707,"about_ca_system_score_gemma":0.000050805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001903451,"about_ca_topic_score_gemma":0.00001779905,"domain_scores_codex":[0.9986159,0.00005476334,0.0002331323,0.000409208,0.0003129671,0.000374007],"domain_scores_gemma":[0.9994348,0.0001899249,0.0000521466,0.0001197966,0.00002066811,0.0001826163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004688864,0.0001664034,0.2157982,0.00001575469,0.000007969586,0.0000966548,0.0001676136,0.000002959825,0.768188,0.0006692815,0.0002980077,0.01454229],"study_design_scores_gemma":[0.002857156,0.001843627,0.2772189,0.0001660945,0.00005012989,0.0003438574,0.0003415175,0.0008641466,0.7120871,0.0007223508,0.003063783,0.0004412929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958469,0.0001830183,0.00007985566,0.00205537,0.0001570341,0.0002251499,0.000007293118,0.00006976427,0.001375665],"genre_scores_gemma":[0.9979893,0.0001240918,0.0002724464,0.0008096498,0.00009009417,0.00000926653,3.637088e-7,0.000005235772,0.0006995576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06142073,"threshold_uncertainty_score":0.9817408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0455286832289002,"score_gpt":0.2799173794948165,"score_spread":0.2343886962659164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}