{"id":"W2362094213","doi":"10.1158/1940-6215.prev-14-a21","title":"Abstract A21: A Phase IIa trial of metformin for colorectal cancer risk reduction among patients with a history of colorectal adenomas and elevated body mass index","year":2015,"lang":"en","type":"article","venue":"Cancer Prevention Research","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Metformin; Colorectal cancer; Internal medicine; Colorectal adenoma; Cancer; Body mass index; Colonoscopy; Gastroenterology; Adenoma; Oncology; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009739496,0.000135907,0.0002790953,0.0001382297,0.00004882435,0.00000954062,0.0001294282,0.0001701622,0.00009414088],"category_scores_gemma":[0.0001515269,0.0001213779,0.00008559756,0.0001630644,0.0003372927,0.00002325605,0.00004394793,0.0001587333,2.713944e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515097,"about_ca_system_score_gemma":0.001141484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007106572,"about_ca_topic_score_gemma":0.0002976096,"domain_scores_codex":[0.9984083,0.0001864798,0.0003427045,0.0003545955,0.0004211163,0.0002868227],"domain_scores_gemma":[0.9983713,0.00002192044,0.000345175,0.0001663421,0.0009537257,0.0001415384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2506799,0.002520858,0.07009196,0.0007741911,0.001501496,0.000001229885,0.0009022771,0.0002502553,0.4895422,0.00003799641,0.01620324,0.1674944],"study_design_scores_gemma":[0.1815345,0.01519253,0.07307633,0.0002768699,0.0004445602,0.000001169016,0.000576081,0.0007326946,0.6605812,0.0003568982,0.06652201,0.0007052281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9689791,0.02867677,0.000103613,0.000003219239,0.0003852938,0.001501034,0.0002287545,0.000004463932,0.0001177657],"genre_scores_gemma":[0.9911585,0.006652649,0.00008901043,0.000001985456,0.0002207468,0.001078972,0.0001541902,0.000022922,0.0006209826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1710389,"threshold_uncertainty_score":0.4949647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03974246007522765,"score_gpt":0.3578465757007858,"score_spread":0.3181041156255581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}