{"id":"W2362896057","doi":"10.1016/j.exphem.2015.06.235","title":"Musashi-2 postranscriptionally attenuates aryl hydrocarbon receptor signaling to expand human hematopoietic stem cells","year":2015,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McMaster University","funders":"","keywords":"Aryl hydrocarbon receptor; Progenitor cell; Haematopoiesis; Cell biology; Gene knockdown; Biology; Small hairpin RNA; Ex vivo; Stem cell; Cell fate determination; Hematopoietic stem cell; Notch signaling pathway; Signal transduction; In vivo; Apoptosis; Gene; Genetics; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003636747,0.0003261427,0.0002251843,0.0003090974,0.0002179678,0.0003761958,0.000315319,0.0002163635,0.002747821],"category_scores_gemma":[0.0001767702,0.0001942998,0.0002669689,0.000192612,0.0003279737,0.0001950488,0.0002226014,0.000966413,0.0004362497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046174,"about_ca_system_score_gemma":0.0004542488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004434,"about_ca_topic_score_gemma":0.00291691,"domain_scores_codex":[0.9997544,0.00004994461,0.0000248156,0.00003820791,0.00006454794,0.00006805857],"domain_scores_gemma":[0.9998224,0.00005219233,0.00002663726,0.00003038012,0.00001301032,0.00005549749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003105568,0.0001506235,0.0001601716,0.00001786291,0.00000891268,0.00003192423,0.00002235548,0.0001071875,0.9969843,0.0003909572,0.0001394702,0.001675664],"study_design_scores_gemma":[0.00002915767,0.0002467967,0.001033787,0.000001602874,0.00001301213,0.00005441488,0.00002276719,0.0007444671,0.995571,0.00003856952,0.002242488,0.00000196317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935732,0.0008831929,0.002172048,0.0002078132,0.000118677,0.00003634479,0.0003730654,0.0001473133,0.002488254],"genre_scores_gemma":[0.9931365,0.0003264889,0.001377163,0.00007678601,0.00003015035,0.00003161722,0.0004401969,0.00003862151,0.004542398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002747821,"threshold_uncertainty_score":0.009192407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962134625945586,"score_gpt":0.3030029545280603,"score_spread":0.2733816082686044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}