{"id":"W2363071033","doi":"10.1002/path.4741","title":"Wnt disruption in colorectal polyps – the traditional serrated adenoma enters the fray","year":2016,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Cancer Research UK; Wellcome Trust; Wellcome","keywords":"Wnt signaling pathway; Colorectal cancer; Cancer research; Adenoma; Biology; Pathological; Pathogenesis; Lesion; Mouse model of colorectal and intestinal cancer; Hyperplastic Polyp; Cancer; Pathology; Bioinformatics; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003776359,0.0002682784,0.0002933175,0.0007850309,0.0003633394,0.0007700495,0.0001700695,0.0006958303,0.001028712],"category_scores_gemma":[0.0005853359,0.0001589237,0.0002184036,0.0004502604,0.001690799,0.0009180544,0.00067893,0.0006475664,0.0004574454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000561726,"about_ca_system_score_gemma":0.0005008185,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001063154,"about_ca_topic_score_gemma":0.002154726,"domain_scores_codex":[0.9998061,0.00004062103,0.00002503005,0.00003760122,0.00006327545,0.0000273423],"domain_scores_gemma":[0.9997749,0.00003340039,0.00009835652,0.00002303516,0.00001833833,0.00005196288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002416917,0.000131065,0.1042903,0.001702469,0.000175299,0.03115124,0.001822753,0.0008746801,0.504346,0.05174398,0.007045274,0.2943],"study_design_scores_gemma":[0.0001385375,0.001693354,0.3648077,0.0007159523,0.000190168,0.2083457,0.002583129,0.001783213,0.1497471,0.03362168,0.2362337,0.0001397356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8273904,0.1346605,0.005961162,0.01087024,0.0006580677,0.0000508428,0.0003476084,0.0002692371,0.01979204],"genre_scores_gemma":[0.9490247,0.03772328,0.004243659,0.0009340908,0.0003599869,0.00001118977,0.0001678298,0.00004243475,0.007492782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001063154,"threshold_uncertainty_score":0.004075646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02964150706215142,"score_gpt":0.2695204127224479,"score_spread":0.2398789056602965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}