{"id":"W2365630593","doi":"10.1186/s13041-016-0232-4","title":"rAAV-compatible MiniPromoters for restricted expression in the brain and eye","year":2016,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Child and Family Research Institute; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Department of Psychiatry, Faculty of Medicine, University of British Columbia; University of North Carolina at Chapel Hill; Child and Family Research Institute; BC Cancer Agency; Simon Fraser University; Genome Canada; National Institute of General Medical Sciences; Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; Fondation Brain Canada; GlaxoSmithKline","keywords":"Biology; Genetic enhancement; Promoter; Gene expression; Gene delivery; Neuroscience; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005809082,0.0001541141,0.0001235535,0.00008450617,0.00007070375,0.00003256483,0.0003186346,0.0001253271,0.00001088779],"category_scores_gemma":[0.0004349524,0.00009667486,0.00006948598,0.0001410436,0.000105486,0.000004631757,0.00008857703,0.00006960604,0.000003782069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001502759,"about_ca_system_score_gemma":0.00006173537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007301873,"about_ca_topic_score_gemma":0.00005130767,"domain_scores_codex":[0.9985495,0.0003455964,0.0001738532,0.0004040561,0.0001831176,0.0003439394],"domain_scores_gemma":[0.9992308,0.0001282931,0.00004621296,0.0004856068,0.00004176651,0.00006730627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005847248,0.00004416051,0.0003364901,0.00001010338,0.00001371007,0.00001059564,0.00008147257,0.000004527275,0.9813464,0.00002682272,0.009267644,0.008273291],"study_design_scores_gemma":[0.002066753,0.001244064,0.001171907,0.00003367299,0.000003110913,0.000004909898,0.00004744608,0.00003736663,0.9771271,0.0003360691,0.01775879,0.0001687507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97692,0.0005189769,0.006223388,0.01551292,0.0000277577,0.0006332177,0.00002334577,0.000009566907,0.0001308212],"genre_scores_gemma":[0.9948862,0.00003837352,0.000733383,0.003387285,0.00006118609,0.0001638437,0.00005255778,0.00003623757,0.000640967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01796616,"threshold_uncertainty_score":0.3942286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493948295629108,"score_gpt":0.3049038852342251,"score_spread":0.289964402277934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}