{"id":"W2365630593","doi":"10.1186/s13041-016-0232-4","title":"rAAV-compatible MiniPromoters for restricted expression in the brain and eye","year":2016,"lang":"en","type":"article","venue":"Molecular Brain","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; Child and Family Research Institute; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Department of Psychiatry, Faculty of Medicine, University of British Columbia; University of North Carolina at Chapel Hill; Child and Family Research Institute; BC Cancer Agency; Simon Fraser University; Genome Canada; National Institute of General Medical Sciences; Canada's Michael Smith Genome Sciences Centre; Genome British Columbia; Fondation Brain Canada; GlaxoSmithKline","keywords":"Biology; Genetic enhancement; Promoter; Gene expression; Gene delivery; Neuroscience; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004816991,0.0007684199,0.0003908609,0.0006684296,0.0002704204,0.0003822941,0.0005321167,0.0004118954,0.002463754],"category_scores_gemma":[0.0003525213,0.0003758254,0.0004822936,0.0002460456,0.0004168723,0.0003769919,0.0004798684,0.0009796227,0.001872448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866149,"about_ca_system_score_gemma":0.000401593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003850642,"about_ca_topic_score_gemma":0.0009366713,"domain_scores_codex":[0.9995982,0.00005587337,0.00004935295,0.0001060559,0.0001335547,0.00005697184],"domain_scores_gemma":[0.99957,0.00009468159,0.0001463081,0.00008592187,0.000049658,0.00005337672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005971169,0.0000192909,0.0001199261,0.00004030008,0.000006060757,0.00003716571,0.00002088837,0.00009940484,0.9973598,0.0002370868,0.0000892625,0.001911127],"study_design_scores_gemma":[0.00001854289,0.0001740812,0.0008147249,0.00001170458,0.00001977645,0.0003475853,0.00001437529,0.0006970067,0.9908827,0.00006879475,0.006943688,0.0000070241],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8221941,0.002741293,0.1610766,0.0002450828,0.0001548359,0.001363852,0.005135486,0.001991983,0.005096695],"genre_scores_gemma":[0.8329504,0.00278425,0.1390537,0.0001466304,0.00004137359,0.001540668,0.009294023,0.0008168112,0.01337203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002463754,"threshold_uncertainty_score":0.008242071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01493948295629108,"score_gpt":0.3049038852342251,"score_spread":0.289964402277934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}