{"id":"W2365764378","doi":"10.1021/acs.langmuir.5b03271","title":"Chain Length of Free Fatty Acids Influences the Phase Behavior of Stratum Corneum Model Membranes","year":2015,"lang":"en","type":"article","venue":"Langmuir","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Stratum corneum; Chemistry; Corneocyte; Membrane; Palmitic acid; Lamellar structure; Phase (matter); Phospholipid; Fatty acid; Crystallography; Lipid bilayer phase behavior; Sphingolipid; Lipid bilayer; Organic chemistry; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004684521,0.0001752832,0.0002746323,0.00005646573,0.00008624738,0.000004866068,0.0006151802,0.0001806024,0.0001441245],"category_scores_gemma":[0.0000533962,0.0001290521,0.00008299114,0.0001489594,0.0005205285,0.0001427631,0.00009444106,0.0004152604,0.00001081073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002000635,"about_ca_system_score_gemma":0.00008556537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003273648,"about_ca_topic_score_gemma":0.00002267611,"domain_scores_codex":[0.9986834,0.000210773,0.0003870912,0.0001894824,0.0002541022,0.0002751451],"domain_scores_gemma":[0.9990942,0.0001489418,0.0001943334,0.0003109016,0.0001460075,0.0001056137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004259413,0.00739024,0.09020025,0.0009739075,0.00117541,0.000182522,0.02613105,0.101266,0.7033312,0.01724403,0.01237234,0.03547372],"study_design_scores_gemma":[0.01671293,0.000981965,0.007802558,0.00005895622,0.001285282,0.00003871583,0.003801017,0.08578712,0.855129,0.004787391,0.02277265,0.0008424175],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939944,0.0009789964,0.000731041,0.0003268862,0.0004476089,0.0003843976,0.0005212279,0.00004436264,0.002571134],"genre_scores_gemma":[0.9985571,0.0001190454,0.0003496846,0.000460375,0.00007611512,0.00005698131,0.00002672913,0.00001691976,0.0003370822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1517978,"threshold_uncertainty_score":0.5262594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1943328808600508,"score_gpt":0.454274057204713,"score_spread":0.2599411763446622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}