{"id":"W2369258731","doi":"10.1371/journal.pgen.1005980","title":"Hypothalamic Leptin Resistance: From BBB to BBSome","year":2016,"lang":"en","type":"letter","venue":"PLoS Genetics","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Xunta de Galicia; Instituto de Salud Carlos III; Universitetet i Bergen; Ministerio de Economía y Competitividad","keywords":"Leptin; Leptin receptor; Internal medicine; Endocrinology; Biology; Hypothalamus; Neuropeptide Y receptor; Signal transduction; SOCS3; Receptor; Proopiomelanocortin; Neuropeptide; Cell biology; STAT3; Obesity; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006698254,0.0003696533,0.000373575,0.0001588185,0.0001589639,0.0001146992,0.0008404372,0.0005571511,0.0006181956],"category_scores_gemma":[0.0002667355,0.0003191216,0.0001347116,0.0001876919,0.0001135826,0.00005121862,0.0001997684,0.0006799436,0.003736607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000918722,"about_ca_system_score_gemma":0.0000708802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003184336,"about_ca_topic_score_gemma":0.00001512368,"domain_scores_codex":[0.9970995,0.0002062463,0.0003778835,0.0009529137,0.0008190838,0.0005443582],"domain_scores_gemma":[0.9979717,0.000500765,0.000253179,0.001091246,0.0000668357,0.0001163104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001290445,0.00001797482,0.0002134275,0.00003090571,0.0000118164,0.0000924611,0.00006512649,0.000006170178,0.2481958,0.00001526516,0.7509282,0.0004099043],"study_design_scores_gemma":[0.0001243102,0.00002276308,0.0003453984,0.00009587422,0.00002668345,7.420899e-7,8.680165e-7,0.00001530563,0.3983287,0.001594826,0.5991623,0.0002821732],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.5425264,0.0002678921,0.0001541988,0.4429748,0.0009866025,0.0006816913,0.001383102,0.0002197217,0.01080552],"genre_scores_gemma":[0.01708949,0.0007406919,0.002295575,0.8806093,0.01468808,0.0000596173,0.00009923331,0.0002418185,0.08417621],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5254369,"threshold_uncertainty_score":0.9999261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0423353258860915,"score_gpt":0.2446562012213448,"score_spread":0.2023208753352533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}