{"id":"W2369258731","doi":"10.1371/journal.pgen.1005980","title":"Hypothalamic Leptin Resistance: From BBB to BBSome","year":2016,"lang":"en","type":"letter","venue":"PLoS Genetics","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición; Xunta de Galicia; Instituto de Salud Carlos III; Universitetet i Bergen; Ministerio de Economía y Competitividad","keywords":"Leptin; Leptin receptor; Internal medicine; Endocrinology; Biology; Hypothalamus; Neuropeptide Y receptor; Signal transduction; SOCS3; Receptor; Proopiomelanocortin; Neuropeptide; Cell biology; STAT3; Obesity; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007048327,0.0004540674,0.0006459062,0.0003415346,0.0008215432,0.001557294,0.0005568134,0.005840495,0.002966856],"category_scores_gemma":[0.00402847,0.0002109629,0.0004868655,0.0002254892,0.001911488,0.00148545,0.0008168615,0.0138795,0.002639748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001445696,"about_ca_system_score_gemma":0.0007886122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001222217,"about_ca_topic_score_gemma":0.001283949,"domain_scores_codex":[0.9995795,0.00006870971,0.00004688662,0.00009948603,0.0001392125,0.00006630504],"domain_scores_gemma":[0.998868,0.0005356468,0.0001478745,0.0000795434,0.0001899912,0.0001789237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001323307,0.0001229824,0.002664995,0.0005894261,0.0001204315,0.02259328,0.0003451983,0.0001239853,0.01745906,0.04306442,0.7769879,0.1346051],"study_design_scores_gemma":[0.0003861034,0.000341521,0.005361424,0.0007044455,0.0001166271,0.02491904,0.0005468908,0.0004593065,0.00642314,0.04958599,0.9110438,0.0001117534],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.006617403,0.02982297,0.001274549,0.9226028,0.03290157,0.00001545699,0.0001395595,0.0001827135,0.006443053],"genre_scores_gemma":[0.1257444,0.06154394,0.00155664,0.6780932,0.1099259,0.0000823382,0.0001724603,0.0001280909,0.02275303],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005840495,"threshold_uncertainty_score":0.01048928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0423353258860915,"score_gpt":0.2446562012213448,"score_spread":0.2023208753352533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}