{"id":"W2369799003","doi":"10.1016/j.nbd.2016.05.002","title":"The glial cell modulator ibudilast attenuates neuroinflammation and enhances retinal ganglion cell viability in glaucoma through protein kinase A signaling","year":2016,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Glaucoma and retinal disorders","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Neuroinflammation; Gliosis; Proinflammatory cytokine; Muller glia; Retinal ganglion cell; Neuroprotection; Retina; Medicine; Protein kinase A; Neuroscience; Pharmacology; Cell biology; Kinase; Immunology; Biology; Inflammation; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861531,0.0001753963,0.0002389027,0.00004804164,0.0001010804,0.000008278557,0.0001031837,0.00007438738,0.00001735234],"category_scores_gemma":[0.0002594697,0.00009927108,0.00008648267,0.0001096402,0.0004938861,0.00008112332,0.00005919637,0.000134766,0.000008330863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000016577,"about_ca_system_score_gemma":0.00007210426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001642402,"about_ca_topic_score_gemma":0.000009788055,"domain_scores_codex":[0.9985897,0.0002780385,0.0003609459,0.0003740414,0.0001193314,0.0002779295],"domain_scores_gemma":[0.9991304,0.0002455899,0.0001671543,0.0002624169,0.00007727691,0.0001171952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002057389,0.0001989595,0.1692574,0.0002243415,0.000003998112,0.00001921741,0.00007338607,7.141018e-7,0.8277251,0.0000438178,0.00002413258,0.0003714883],"study_design_scores_gemma":[0.00208636,0.0008659385,0.5622059,0.0001614867,0.00005685529,0.000003499027,0.000080356,0.00007041115,0.4330348,0.00111087,0.0001824054,0.0001411652],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957221,0.0001805503,0.00002362797,0.003002782,0.0001074867,0.0007855277,0.00001728345,0.00002688599,0.0001337169],"genre_scores_gemma":[0.9995884,0.00005162485,0.00006280575,0.00006608332,0.00006207621,0.00004104201,0.000006830295,0.00001467867,0.0001064201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3946903,"threshold_uncertainty_score":0.4048157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006093344187058932,"score_gpt":0.219730486105461,"score_spread":0.2136371419184021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}