{"id":"W237125283","doi":"10.1096/fasebj.27.1_supplement.138.7","title":"NLRP3 Inflammasome is terminated by PGE <sup>2</sup> ‐cAMP‐PKA signaling","year":2013,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Inflammasome; Forskolin; Nigericin; Prostaglandin E2 receptor; Cell biology; Chemistry; Caspase 1; Prostaglandin E; Signal transduction; Inflammation; AIM2; Innate immune system; Agonist; Mediator; Biology; Biochemistry; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002990062,0.0003727054,0.0004415264,0.0001920066,0.0001958987,0.0005664482,0.0001461187,0.0004347963,0.002232102],"category_scores_gemma":[0.0002514147,0.000216087,0.0003935782,0.0001486683,0.0005108928,0.000466353,0.00037667,0.001000582,0.001038996],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003701545,"about_ca_system_score_gemma":0.0003376445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003044524,"about_ca_topic_score_gemma":0.0004010813,"domain_scores_codex":[0.9997527,0.00005505647,0.00002564713,0.00003898477,0.00006484213,0.00006279173],"domain_scores_gemma":[0.9998559,0.00002695251,0.00005045968,0.00002651472,0.0000166956,0.00002348689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002851746,0.00001354118,0.00009146745,0.00005191909,0.000003473897,0.0001105777,0.00001091596,0.00003404012,0.998516,0.0001513423,0.00005983178,0.0006716417],"study_design_scores_gemma":[0.00005873812,0.0002052153,0.006176958,0.00002056257,0.00001045339,0.0007407039,0.00003741628,0.0004333542,0.9869618,0.0003793089,0.004969499,0.000005992973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639716,0.01265,0.0128274,0.001057856,0.0002990692,0.0001386972,0.001502543,0.0002904899,0.0072624],"genre_scores_gemma":[0.982533,0.003725595,0.006336906,0.0002575109,0.00006368622,0.0001123182,0.0008532982,0.00004549791,0.006072255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002232102,"threshold_uncertainty_score":0.007467151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005515159547319784,"score_gpt":0.2088293633229017,"score_spread":0.2033142037755819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}