{"id":"W2371536864","doi":"10.1016/j.chom.2016.04.005","title":"HIV-1 Vpu Mediates HLA-C Downregulation","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Downregulation and upregulation; Immune system; Cytotoxic T cell; Human leukocyte antigen; Virology; Immunology; Viral replication; In vitro; Virus; Antigen; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001377908,0.0001963815,0.0001900739,0.0001266489,0.0001711933,0.00001979479,0.000165662,0.0002507682,0.01166794],"category_scores_gemma":[0.00004031858,0.0001377127,0.0001189767,0.00009646304,0.0001353772,0.0002235622,0.00006641052,0.0001610798,0.02555244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008175849,"about_ca_system_score_gemma":0.00003203391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002505581,"about_ca_topic_score_gemma":0.000003964737,"domain_scores_codex":[0.9989005,0.0001090059,0.0003040421,0.0003167664,0.00002791513,0.0003417991],"domain_scores_gemma":[0.999289,0.0001266288,0.0001446354,0.00031881,0.00009656791,0.00002435038],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009386057,0.00007333148,0.0006929984,0.00000739272,0.00002603227,9.707966e-7,0.0001317474,4.219796e-7,0.8544393,0.00008198818,0.1408747,0.003577228],"study_design_scores_gemma":[0.0008436823,0.00005260524,0.003528427,0.00002343386,0.00001624997,0.0000215907,0.00005391688,5.632297e-7,0.5626242,0.00002170502,0.4326821,0.000131596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9315255,0.006140824,0.004401318,0.003260134,0.0138429,0.0005664775,0.00004986577,0.0005286041,0.03968443],"genre_scores_gemma":[0.826778,0.0002058314,0.00005643065,0.0003405488,0.00008815145,0.00001305607,0.0001897673,0.00002475331,0.1723035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2918152,"threshold_uncertainty_score":0.9892355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006382458816173112,"score_gpt":0.2010154488023281,"score_spread":0.194632989986155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}