{"id":"W2371536864","doi":"10.1016/j.chom.2016.04.005","title":"HIV-1 Vpu Mediates HLA-C Downregulation","year":2016,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":138,"is_retracted":false,"has_abstract":false,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Downregulation and upregulation; Immune system; Cytotoxic T cell; Human leukocyte antigen; Virology; Immunology; Viral replication; In vitro; Virus; Antigen; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007374,0.0004859596,0.0002802543,0.0003067635,0.0005117084,0.00108975,0.0005327124,0.0005614373,0.004986598],"category_scores_gemma":[0.0004077181,0.0002234142,0.0003763418,0.0001625568,0.000404255,0.0004215689,0.000551071,0.00110405,0.001268405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008117425,"about_ca_system_score_gemma":0.0004382762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001825163,"about_ca_topic_score_gemma":0.001042761,"domain_scores_codex":[0.9996507,0.00006564039,0.00001754276,0.00005405974,0.00004792777,0.0001641558],"domain_scores_gemma":[0.9997544,0.00007350818,0.00002617273,0.00005875279,0.00002870444,0.00005845562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002839154,0.00005713442,0.0002839281,0.00003208008,0.000007262025,0.0001457028,0.00002360276,0.0000889736,0.996694,0.0005003489,0.0001798422,0.001703167],"study_design_scores_gemma":[0.00003666805,0.0001682656,0.00948622,0.00001069451,0.00001241254,0.0005486191,0.0001001686,0.001793858,0.9845585,0.000274927,0.003001458,0.000008209172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902061,0.001730952,0.001631764,0.0001621467,0.0001011592,0.00003388245,0.0004341433,0.0001137633,0.005586192],"genre_scores_gemma":[0.9958206,0.0003975225,0.0004995044,0.00006289119,0.00002013397,0.00002537484,0.0003083759,0.00002560986,0.002839877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004986598,"threshold_uncertainty_score":0.01668179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006382458816173112,"score_gpt":0.2010154488023281,"score_spread":0.194632989986155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}