{"id":"W2372521931","doi":"10.1016/j.jad.2016.05.013","title":"Brexpiprazole as adjunctive treatment of major depressive disorder with anxious distress: Results from a post-hoc analysis of two randomised controlled trials","year":2016,"lang":"en","type":"article","venue":"Journal of Affective Disorders","topic":"Treatment of Major Depression","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Otsuka Pharmaceutical Development and Commercialization; H. Lundbeck A/S","keywords":"Akathisia; Adjunctive treatment; Placebo; Major depressive disorder; Clinical endpoint; Post-hoc analysis; Psychology; Internal medicine; Randomized controlled trial; Psychiatry; Medicine; Antipsychotic; Schizophrenia (object-oriented programming); Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"design_other","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007986117,0.003030125,0.0117265,0.001104573,0.000713995,0.002215537,0.001829738,0.002756633,0.00672606],"category_scores_gemma":[0.01317279,0.001275484,0.01007578,0.001206,0.002317146,0.002450303,0.001028928,0.00405087,0.0007145219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001919152,"about_ca_system_score_gemma":0.001822443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002043137,"about_ca_topic_score_gemma":0.004660062,"domain_scores_codex":[0.991303,0.005511089,0.001111141,0.0007874799,0.0005596885,0.0007276375],"domain_scores_gemma":[0.9896032,0.006530247,0.001840508,0.0007215737,0.0006448009,0.000659579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9851266,0.0006678386,0.0002494023,0.001878448,0.007045042,0.00003046897,0.0000414793,0.0001252483,0.0008160744,0.00003820218,0.0001202057,0.003860983],"study_design_scores_gemma":[0.9528412,0.02900677,0.002194405,0.0001529187,0.01462616,0.00003296182,0.00005068121,0.0002507207,0.0003549163,0.00009292713,0.0003629549,0.00003328212],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447332,0.03884169,0.002361096,0.0007986541,0.001719978,0.007975627,0.001570373,0.0001905053,0.001808949],"genre_scores_gemma":[0.9749309,0.0126865,0.002628157,0.0006001751,0.0006880286,0.005066868,0.001028312,0.00006376726,0.002307337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0117265,"threshold_uncertainty_score":0.04223514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00960854355383766,"score_gpt":0.2953233333632217,"score_spread":0.285714789809384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}