{"id":"W2374649359","doi":"10.1073/pnas.1512947113","title":"Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Pilin; Biology; Transcription (linguistics); Pilus; Cell biology; Transcription factor; Two-component regulatory system; Periplasmic space; Protein subunit; Mutant; Genetics; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003978852,0.00008579252,0.0000884504,0.00003516414,0.0001864949,0.00001846705,0.0003106728,0.00006003698,0.00001002327],"category_scores_gemma":[0.0001696973,0.00003273262,0.00004556448,0.000204309,0.0006016671,0.00002794847,0.0001008741,0.00006518513,8.027563e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008192898,"about_ca_system_score_gemma":0.00002219801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002812138,"about_ca_topic_score_gemma":3.773729e-7,"domain_scores_codex":[0.9992641,0.00001029513,0.0001459329,0.0002003619,0.0002608074,0.0001185403],"domain_scores_gemma":[0.9994595,0.00004838296,0.0002338312,0.00001708907,0.0002167316,0.00002446916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008853024,0.00001704129,0.0002043148,0.000006898007,0.00001203821,3.582685e-9,0.00004176494,0.000005903656,0.9978458,0.000253887,0.000507391,0.001016414],"study_design_scores_gemma":[0.0001232767,0.00009239678,0.003784274,0.00009302163,0.000006831274,0.00001145885,0.00007144677,0.00003245707,0.991227,0.000250038,0.004245559,0.00006222678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929345,0.00004420439,0.000002511371,0.005499603,0.00003597067,0.0001024467,0.00001303599,0.000004999828,0.001362719],"genre_scores_gemma":[0.9987819,0.00004416083,0.0004394391,0.0001916781,0.0001531237,0.000002352771,3.313834e-7,0.000004582473,0.0003824986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0066188,"threshold_uncertainty_score":0.2216868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967442255489905,"score_gpt":0.2637922395036192,"score_spread":0.2441178169487202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}