{"id":"W2374649359","doi":"10.1073/pnas.1512947113","title":"Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS","year":2016,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Pilin; Biology; Transcription (linguistics); Pilus; Cell biology; Transcription factor; Two-component regulatory system; Periplasmic space; Protein subunit; Mutant; Genetics; Gene; Virulence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008318308,0.0003370979,0.0001261468,0.0001621934,0.000158508,0.0003335102,0.0001248753,0.0001326795,0.001144586],"category_scores_gemma":[0.000181985,0.000117181,0.0001450115,0.00007674811,0.0002393233,0.0002074178,0.0004114651,0.0003513617,0.0005342932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005698194,"about_ca_system_score_gemma":0.0001696046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005553182,"about_ca_topic_score_gemma":0.0007988235,"domain_scores_codex":[0.9998394,0.00002727253,0.000005632418,0.00002337526,0.00005838794,0.0000458457],"domain_scores_gemma":[0.9999099,0.00001576394,0.00002819323,0.000007530411,0.00001181739,0.00002682385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002280944,0.000004847374,0.0001755194,0.000007919481,0.000001033345,0.00001327068,0.000006156803,0.0000285703,0.998952,0.0001429401,0.00002968788,0.0006150676],"study_design_scores_gemma":[0.000008364043,0.0000638248,0.01165181,0.000005434253,0.000004952607,0.00009851395,0.00005861346,0.001905905,0.9834182,0.0002717866,0.002508448,0.000004249242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894093,0.001217776,0.004709564,0.0002033387,0.00002242915,0.00001603872,0.0001507226,0.0001266785,0.004144163],"genre_scores_gemma":[0.9965624,0.0002283367,0.0009532108,0.00002588274,0.000004978369,0.00001035697,0.0001193335,0.00001327378,0.00208215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144586,"threshold_uncertainty_score":0.004134357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01967442255489905,"score_gpt":0.2637922395036192,"score_spread":0.2441178169487202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}