{"id":"W2374991085","doi":"10.1160/th15-11-0910","title":"A randomised, double blind comparison of tecarfarin, a novel vitamin K antagonist, with warfarin","year":2016,"lang":"en","type":"article","venue":"Thrombosis and Haemostasis","topic":"Atrial Fibrillation Management and Outcomes","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute","funders":"","keywords":"Warfarin; Vitamin K antagonist; CYP2C9; Medicine; VKORC1; Internal medicine; Dosing; Pharmacology; Vitamin K epoxide reductase; Gastroenterology; Atrial fibrillation; Cytochrome P450; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003381178,0.001894629,0.00655753,0.0007656526,0.0007639253,0.001166212,0.001521997,0.003720275,0.009865476],"category_scores_gemma":[0.005894767,0.001380378,0.002212622,0.0008211026,0.002311811,0.001787744,0.0007043022,0.002619988,0.001559752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008279995,"about_ca_system_score_gemma":0.001944648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001027156,"about_ca_topic_score_gemma":0.00193482,"domain_scores_codex":[0.9970464,0.001705807,0.0003192535,0.0004439076,0.0002417404,0.0002428354],"domain_scores_gemma":[0.9967153,0.001363091,0.0005975759,0.0004014782,0.0003128063,0.0006098114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9938206,0.002225853,0.00005339604,0.0002985879,0.000263151,0.00001115478,0.00001971483,0.00005426008,0.0008707209,0.00005435496,0.000143314,0.00218483],"study_design_scores_gemma":[0.9764799,0.02273983,0.0002159739,0.00001442546,0.0001190704,0.000009142301,0.000005371591,0.0001107217,0.00008684394,0.000076639,0.0001353103,0.000006736489],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583781,0.00628123,0.002999254,0.0007718904,0.002774873,0.02407406,0.001445605,0.0003343977,0.002940565],"genre_scores_gemma":[0.9395946,0.003824547,0.00593868,0.001530246,0.001396233,0.04101969,0.0008667593,0.00006055149,0.005768746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009865476,"threshold_uncertainty_score":0.03300327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1992292415620819,"score_gpt":0.3960659714116252,"score_spread":0.1968367298495433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}