{"id":"W2375845534","doi":"10.3109/00498254.2016.1173265","title":"Mechanistic investigations into the species differences in pinometostat clearance: impact of binding to alpha-1-acid glycoprotein and permeability-limited hepatic uptake","year":2016,"lang":"en","type":"article","venue":"Xenobiotica","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Plasma protein binding; Blood proteins; Human serum albumin; Glycoprotein; Chemistry; Dissociation constant; Albumin; Hepatocyte; Pharmacology; Biochemistry; Biology; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000319238,0.0002001359,0.0004344952,0.0002170599,0.0001145414,0.00002154502,0.0001412484,0.00008297201,0.0001991173],"category_scores_gemma":[0.0003539665,0.0001004267,0.00009738919,0.0005144284,0.0003493523,0.00006719339,0.00003451755,0.0001380181,0.00001806146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001228647,"about_ca_system_score_gemma":0.0001312198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001324412,"about_ca_topic_score_gemma":0.0002975011,"domain_scores_codex":[0.9986318,0.00006178741,0.0004112801,0.0003160207,0.0002680678,0.0003110265],"domain_scores_gemma":[0.999148,0.0001458186,0.0000812647,0.0003517091,0.00007685748,0.0001964174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003167525,0.0001267421,0.09793006,0.0002167367,0.00006814393,0.0000141826,0.003350788,0.000001266496,0.8914605,0.003457035,0.00001137446,0.003046366],"study_design_scores_gemma":[0.0008648161,0.0008266947,0.9245561,0.0009765932,0.00009707577,0.000008507152,0.0009045687,0.00008550806,0.0680536,0.003352755,0.00007347873,0.0002003378],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948798,0.0001453438,0.001075282,0.002807306,0.00007249819,0.0007432452,0.00003924385,0.0000322245,0.0002050907],"genre_scores_gemma":[0.997674,0.000099872,0.001713105,0.00007512962,0.0000332064,0.00002539309,0.000007049945,0.00001950187,0.0003527074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.826626,"threshold_uncertainty_score":0.4095281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287645543916,"score_gpt":0.2611202244876714,"score_spread":0.2382437690485114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}