{"id":"W2379639368","doi":"10.1021/acs.jproteome.6b00220","title":"An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates","year":2016,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; Wellcome Trust; Wellcome","keywords":"Methyltransferase; Methylation; Lysine; Protein methylation; Immunoprecipitation; Biology; Histone methyltransferase; Enzyme; Computational biology; Cell biology; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002177129,0.0001540702,0.000206794,0.0002919388,0.00012654,0.0000888824,0.0004663042,0.0002211464,0.0000387181],"category_scores_gemma":[0.0002835075,0.00009518615,0.0001319734,0.000270773,0.0002796618,0.00004128705,0.00008259558,0.0003734641,0.00001181515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000127206,"about_ca_system_score_gemma":0.0004666111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001941139,"about_ca_topic_score_gemma":0.00001090653,"domain_scores_codex":[0.9979209,0.0003032168,0.0004366987,0.0003025194,0.000661482,0.0003751433],"domain_scores_gemma":[0.9981191,0.00002647092,0.0002584287,0.0003659279,0.00105943,0.0001706559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003790584,0.0001601488,0.0003018655,0.00002807599,0.00008300229,0.000004911839,0.0001092337,0.00006612422,0.9966039,0.00005873851,0.0005666077,0.001638347],"study_design_scores_gemma":[0.0009020362,0.00105977,0.001336559,0.0001183972,0.000009690602,0.00008339957,0.0002385837,0.0001062454,0.9948564,0.0004994351,0.0006538889,0.0001356298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9655769,0.0006107756,0.03243328,0.0003731477,0.0001085105,0.0006607058,0.00001075448,0.00000542099,0.000220506],"genre_scores_gemma":[0.9934484,0.0001795397,0.003956433,0.000004052167,0.000949389,0.00005757706,0.00001131164,0.00003105588,0.001362278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02847684,"threshold_uncertainty_score":0.3881579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795322608302232,"score_gpt":0.3462933023728356,"score_spread":0.3083400762898133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}