{"id":"W2379639368","doi":"10.1021/acs.jproteome.6b00220","title":"An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates","year":2016,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Structural Genomics Consortium; Wellcome Trust; Wellcome","keywords":"Methyltransferase; Methylation; Lysine; Protein methylation; Immunoprecipitation; Biology; Histone methyltransferase; Enzyme; Computational biology; Cell biology; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003279383,0.0006384085,0.0005307508,0.0004453763,0.0002889487,0.0004974451,0.0003289099,0.0003645682,0.0006014093],"category_scores_gemma":[0.0001765112,0.0002347111,0.00047323,0.0002431172,0.0001839292,0.0003625218,0.0003977764,0.0006026567,0.000427304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226468,"about_ca_system_score_gemma":0.0003108605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002897829,"about_ca_topic_score_gemma":0.0008416417,"domain_scores_codex":[0.9998566,0.0000147568,0.00001083594,0.00004420499,0.00005050025,0.00002304506],"domain_scores_gemma":[0.9998977,0.00001620998,0.00001915935,0.00001366191,0.00002398241,0.00002928766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004492169,0.00000857667,0.0003177004,0.00002551693,0.00001020268,0.00003612745,0.000006221418,0.0000305449,0.9985048,0.00003746507,0.0000192208,0.0009588158],"study_design_scores_gemma":[0.00001617965,0.0001299747,0.009551917,0.000004715178,0.00006037697,0.0006656459,0.00004269503,0.002971157,0.9835496,0.0001378847,0.002857571,0.00001225926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444669,0.002704285,0.04892717,0.0003321078,0.00007473769,0.0001112405,0.001353976,0.0002993727,0.001730121],"genre_scores_gemma":[0.9028534,0.002158928,0.08814628,0.0002877041,0.00005050902,0.0001004204,0.004107716,0.00008814039,0.002206877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006384085,"threshold_uncertainty_score":0.002340913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03795322608302232,"score_gpt":0.3462933023728356,"score_spread":0.3083400762898133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}