{"id":"W2380648876","doi":"10.1039/9781849737814-00248","title":"Design and Development of NS5B Polymerase Non‐nucleoside Inhibitors for the Treatment of Hepatitis C Virus Infection","year":2013,"lang":"en","type":"book-chapter","venue":"","topic":"Hepatitis C virus research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS5B; Hepatitis C virus; Druggability; Virology; RNA polymerase; Ribavirin; Allosteric regulation; Drug discovery; Interferon; Virus; Biology; Medicine; RNA; Hepacivirus; Bioinformatics; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047679,0.0007193763,0.0004888079,0.0004341436,0.0002462152,0.0006876994,0.0005459537,0.0005808328,0.003332815],"category_scores_gemma":[0.0001952099,0.0003563922,0.0005548243,0.0002789369,0.0001826511,0.000514883,0.0004763694,0.0009952177,0.001814622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004164084,"about_ca_system_score_gemma":0.0005476685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004683617,"about_ca_topic_score_gemma":0.001387854,"domain_scores_codex":[0.9998347,0.00002488405,0.00001038914,0.00002573683,0.00006766863,0.00003668475],"domain_scores_gemma":[0.9999588,0.000003940414,0.000008785821,0.000002841822,0.00001273933,0.00001287297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000757924,0.0009320993,0.000454092,0.003795145,0.0001624836,0.0007629119,0.0002546205,0.007038825,0.6028472,0.01913306,0.01373893,0.3501226],"study_design_scores_gemma":[0.0008756199,0.01112823,0.002225849,0.0008338516,0.0002904,0.001823524,0.00008575631,0.00707464,0.3558533,0.002899192,0.6167932,0.0001164946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2390245,0.5515958,0.06928349,0.003457634,0.002658419,0.003479501,0.003869893,0.00126704,0.1253637],"genre_scores_gemma":[0.5382021,0.3379094,0.059938,0.00255757,0.0004026396,0.001702434,0.003602211,0.0001508531,0.05553473],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003332815,"threshold_uncertainty_score":0.01114941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05808669782265448,"score_gpt":0.3043926376752817,"score_spread":0.2463059398526273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}