{"id":"W2381270640","doi":"10.1038/srep25853","title":"Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Eye Institute; National Medical Research Council; National Health and Medical Research Council; Fundamental Research Funds for the Central Universities; National Institutes of Health; Moorfields Eye Hospital NHS Foundation Trust; Medical Research Council; Sun Yat-sen University; Curtin University of Technology; Jyväskylän Yliopisto; Wellcome Trust; Ophthalmic Research Institute of Australia; Hong Kong Polytechnic University; Biomedical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Raine Medical Research Foundation; QIMR Berghofer Medical Research Institute; Pfizer Australia; University of Bristol; National Institute for Health and Care Research; National Natural Science Foundation of China; Research to Prevent Blindness; Southwest Hospital; American Health Assistance Foundation; Pfizer; National Science Fund for Distinguished Young Scholars; National Science Foundation","keywords":"Genome-wide association study; Refractive error; Genetic variants; Genetic association; Genetics; Biology; Medicine; Demography; Gene; Physiology; Genotype; Single-nucleotide polymorphism; Eye disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002308367,0.0004429889,0.0004963999,0.00059211,0.0008417728,0.001187213,0.0005477056,0.0006063444,0.004125786],"category_scores_gemma":[0.004132716,0.0002475563,0.001047709,0.001090561,0.0003692587,0.0002982552,0.001926693,0.0006731764,0.0004422566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004408546,"about_ca_system_score_gemma":0.0009466526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02081272,"about_ca_topic_score_gemma":0.02935756,"domain_scores_codex":[0.9986659,0.0004331995,0.00007396581,0.0004729983,0.0001913663,0.0001626528],"domain_scores_gemma":[0.9983265,0.0004108491,0.0004146587,0.0004009596,0.0002126639,0.0002343595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003190044,0.0001081635,0.9650289,0.0001511049,0.001463118,0.0006889272,0.0006186868,0.0006882324,0.006319155,0.0007264189,0.003366799,0.01765054],"study_design_scores_gemma":[0.0001010878,0.0001517431,0.9925557,0.0000532622,0.0005956731,0.0007216007,0.000212521,0.0004159404,0.0009334147,0.0003332608,0.003905212,0.00002075123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879952,0.00124269,0.0009343486,0.0002895997,0.00003605424,0.00003050461,0.007293072,0.0000321303,0.002146424],"genre_scores_gemma":[0.9870429,0.0006427157,0.002037991,0.0002127268,0.00003848366,0.0001145407,0.00702487,0.0000534524,0.002832288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02081272,"threshold_uncertainty_score":0.04138315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135220837987664,"score_gpt":0.2808693647178459,"score_spread":0.2673472809190795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}