{"id":"W2381270640","doi":"10.1038/srep25853","title":"Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ophthalmology and Visual Impairment Studies","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Eye Institute; National Medical Research Council; National Health and Medical Research Council; Fundamental Research Funds for the Central Universities; National Institutes of Health; Moorfields Eye Hospital NHS Foundation Trust; Medical Research Council; Sun Yat-sen University; Curtin University of Technology; Jyväskylän Yliopisto; Wellcome Trust; Ophthalmic Research Institute of Australia; Hong Kong Polytechnic University; Biomedical Research Council; Institute of Psychiatry, Psychology and Neuroscience, King’s College London; Raine Medical Research Foundation; QIMR Berghofer Medical Research Institute; Pfizer Australia; University of Bristol; National Institute for Health and Care Research; National Natural Science Foundation of China; Research to Prevent Blindness; Southwest Hospital; American Health Assistance Foundation; Pfizer; National Science Fund for Distinguished Young Scholars; National Science Foundation","keywords":"Genome-wide association study; Refractive error; Genetic variants; Genetic association; Genetics; Biology; Medicine; Demography; Gene; Physiology; Genotype; Single-nucleotide polymorphism; Eye disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004528494,0.0001341606,0.0002611979,0.00007018027,0.0003086715,0.00002272091,0.00003185104,0.0000503474,0.00004133031],"category_scores_gemma":[0.0003963202,0.00006623299,0.00003248144,0.00008516484,0.0008444027,0.00008167758,0.00009201034,0.0001018045,0.000003497231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000042116,"about_ca_system_score_gemma":0.00004882558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001652695,"about_ca_topic_score_gemma":0.000007890384,"domain_scores_codex":[0.9987162,0.0000911893,0.0002857166,0.0004501327,0.0002618406,0.000194891],"domain_scores_gemma":[0.9989122,0.000263175,0.000318725,0.0003569695,0.00005972023,0.00008927893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001310526,0.001880111,0.9206708,0.00007108953,0.0009040822,0.001713849,0.002478503,0.00000158301,0.06983586,0.00001093308,0.0006699442,0.001632192],"study_design_scores_gemma":[0.0007330508,0.001050888,0.9866248,0.000256885,0.0003184328,0.001462776,0.0002014415,0.000002759903,0.008777224,0.0004014183,0.00008541773,0.00008487879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976745,0.0002824214,0.00005247094,0.0004579135,0.0007275944,0.0006139357,0.000003680791,0.00001628671,0.0001711967],"genre_scores_gemma":[0.9959421,0.00004247223,0.00008796216,0.00003365199,0.00002084575,0.00004107049,0.000003941601,0.0000105446,0.003817448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06595402,"threshold_uncertainty_score":0.3111237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135220837987664,"score_gpt":0.2808693647178459,"score_spread":0.2673472809190795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}