{"id":"W2382461064","doi":"10.1200/jco.2013.31.15_suppl.cra9003","title":"Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"GNAQ; Medicine; Temozolomide; Melanoma; Selumetinib; Internal medicine; Oncology; Cancer; Cancer research; Mutation; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00330978,0.0002748256,0.002807502,0.0003327036,0.00007789859,0.000006348278,0.0003058213,0.0007560209,0.0007451097],"category_scores_gemma":[0.003658243,0.0001976578,0.0005501054,0.0003041923,0.0003202091,0.0001892437,0.0001468753,0.001400429,0.00009484011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002845406,"about_ca_system_score_gemma":0.001435024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002714249,"about_ca_topic_score_gemma":0.0006315915,"domain_scores_codex":[0.9935781,0.001211674,0.003917158,0.0003544308,0.0004958682,0.0004427409],"domain_scores_gemma":[0.9929118,0.003205183,0.002438813,0.000388531,0.0005234219,0.0005322229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03164602,0.1161228,0.615262,0.00004093494,0.002678736,0.008763924,0.001125134,0.00001291521,0.0006325275,0.00006942903,0.002456475,0.2211891],"study_design_scores_gemma":[0.204122,0.3720128,0.4067753,0.0001057362,0.001679317,0.0005771712,0.002146394,0.00009984397,0.0002684023,0.0002322389,0.01177678,0.0002040173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906325,0.0002488201,0.00000668041,0.003199429,0.002091811,0.0008976691,0.00000440002,0.00001347486,0.002905194],"genre_scores_gemma":[0.9967421,0.0001505837,0.001558618,0.0005712395,0.0006064067,0.00002228814,0.000004681444,0.00002733098,0.0003167128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.25589,"threshold_uncertainty_score":0.8158429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176640819480776,"score_gpt":0.4830187535876331,"score_spread":0.3653546716395555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}