{"id":"W2382461064","doi":"10.1200/jco.2013.31.15_suppl.cra9003","title":"Phase II study of selumetinib (sel) versus temozolomide (TMZ) in gnaq/Gna11 (Gq/11) mutant (mut) uveal melanoma (UM).","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ocular Oncology and Treatments","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"GNAQ; Medicine; Temozolomide; Melanoma; Selumetinib; Internal medicine; Oncology; Cancer; Cancer research; Mutation; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008321159,0.001045779,0.001623702,0.0003673273,0.0003316436,0.001112094,0.0007222904,0.0008348281,0.004612277],"category_scores_gemma":[0.0007719318,0.0004756523,0.001083662,0.0003285401,0.0005850198,0.001112776,0.0002880366,0.002693239,0.001180708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009883002,"about_ca_system_score_gemma":0.001040461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142901,"about_ca_topic_score_gemma":0.005729556,"domain_scores_codex":[0.9998015,0.00008364302,0.00000895755,0.000035165,0.00002384981,0.00004695368],"domain_scores_gemma":[0.9996233,0.00005713209,0.00005900803,0.00002714013,0.00002534447,0.0002080207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7382727,0.04245108,0.003358003,0.001099239,0.002621372,0.0002339335,0.0002980279,0.004050685,0.03851855,0.0006591149,0.01072208,0.1577152],"study_design_scores_gemma":[0.5538117,0.4154279,0.01257373,0.0000967262,0.001047483,0.0004062229,0.0002307659,0.003000255,0.004768228,0.0007259836,0.007844262,0.00006665251],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808311,0.008036909,0.0006036587,0.001179647,0.000487714,0.001439013,0.001755515,0.0001210473,0.00554533],"genre_scores_gemma":[0.9828596,0.004676592,0.001055388,0.001367082,0.0002303295,0.001315594,0.002322125,0.00003998495,0.006133344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004612277,"threshold_uncertainty_score":0.01542956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1176640819480776,"score_gpt":0.4830187535876331,"score_spread":0.3653546716395555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}