{"id":"W2385169442","doi":"10.1111/bcp.13008","title":"Recommendations for genetic testing to reduce the incidence of anthracycline‐induced cardiotoxicity","year":2016,"lang":"en","type":"review","venue":"British Journal of Clinical Pharmacology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; BC Children's Hospital; Western University; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Guideline; Anthracycline; Medicine; Cardiotoxicity; Genetic testing; Pharmacogenomics; Oncology; Intensive care medicine; Internal medicine; Bioinformatics; Cancer; Pharmacology; Chemotherapy; Biology; Pathology; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02654274,0.001733487,0.002020185,0.004960035,0.001022275,0.002620941,0.005250009,0.01205433,0.01527056],"category_scores_gemma":[0.1059519,0.000720643,0.005650395,0.002094343,0.001402122,0.002929484,0.002468797,0.008463635,0.007594461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003050179,"about_ca_system_score_gemma":0.01326137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01096309,"about_ca_topic_score_gemma":0.01072185,"domain_scores_codex":[0.9715009,0.01499092,0.006574214,0.001295778,0.004770505,0.000867723],"domain_scores_gemma":[0.9089142,0.03770995,0.00840368,0.00285236,0.03884098,0.003278824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0004042616,0.0004808136,0.00328914,0.01659515,0.0006913387,0.0007354821,0.0004661922,0.001885164,0.001589112,0.007474705,0.5969443,0.3694443],"study_design_scores_gemma":[0.00199945,0.0004556865,0.009024139,0.1001213,0.002554323,0.001066753,0.0007099835,0.002313464,0.001703683,0.03096959,0.8488263,0.0002552974],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.004577307,0.1335199,0.06015022,0.6909564,0.01457457,0.009237464,0.01046105,0.002851183,0.07367184],"genre_scores_gemma":[0.05094801,0.1322357,0.2892533,0.4625041,0.008178394,0.01790104,0.01599948,0.0007509796,0.02222898],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.02654274,"threshold_uncertainty_score":0.1403731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2498885171904753,"score_gpt":0.5198893829645916,"score_spread":0.2700008657741163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}