{"id":"W2385607667","doi":"10.1021/acsnano.5b02796","title":"Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles","year":2015,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Planning and Budgeting Committee of the Council for Higher Education of Israel; Israel Science Foundation; Center for Nanoscience and Nanotechnology, Tel Aviv University; European Research Council; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Small interfering RNA; RNA interference; Gene silencing; Systemic administration; Immune system; Biology; Transfection; Cancer research; Cell biology; T cell; Immunology; In vivo; Cell culture; RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981285,0.0001353983,0.0001585539,0.00006050621,0.00003425476,0.00002400862,0.0001840487,0.0001226007,0.0000036059],"category_scores_gemma":[0.0000603357,0.0001299748,0.00004283794,0.0001234499,0.00003414669,0.00001001627,0.0001216114,0.00004126874,0.00003112621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001056157,"about_ca_system_score_gemma":0.0002694826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001291065,"about_ca_topic_score_gemma":0.0000207663,"domain_scores_codex":[0.9990275,0.00006136546,0.0002426737,0.0002804898,0.0001195889,0.0002684142],"domain_scores_gemma":[0.9994791,0.000007204263,0.00006827446,0.0002715327,0.00009111603,0.00008275497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006744589,0.00002883048,0.00714861,0.00001446065,0.0000160259,0.000009944148,0.0001278333,0.0006391314,0.9908926,0.000002178256,0.0004049189,0.0006480057],"study_design_scores_gemma":[0.0006243123,0.0001407871,0.0007365361,0.00005403632,0.00001000596,0.00007149004,0.0002084606,0.0002173494,0.9974443,0.00001242437,0.0003057156,0.0001745537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995317,0.003976513,0.00009029741,0.00001481197,0.0002676383,0.0001035477,0.000006514706,0.00001416529,0.0002095459],"genre_scores_gemma":[0.9987216,0.0001526774,0.0004728741,0.0002388008,0.000207969,0.00001003915,0.00004190765,0.00001822883,0.0001359082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006551713,"threshold_uncertainty_score":0.5300218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02326445968183091,"score_gpt":0.2422302050791,"score_spread":0.2189657453972691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}