{"id":"W2385607667","doi":"10.1021/acsnano.5b02796","title":"Systemic Gene Silencing in Primary T Lymphocytes Using Targeted Lipid Nanoparticles","year":2015,"lang":"en","type":"article","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; Planning and Budgeting Committee of the Council for Higher Education of Israel; Israel Science Foundation; Center for Nanoscience and Nanotechnology, Tel Aviv University; European Research Council; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Small interfering RNA; RNA interference; Gene silencing; Systemic administration; Immune system; Biology; Transfection; Cancer research; Cell biology; T cell; Immunology; In vivo; Cell culture; RNA; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001606201,0.0005097985,0.0003522147,0.0001550196,0.0001328244,0.0003863327,0.000177962,0.0004210499,0.0006345798],"category_scores_gemma":[0.0001176319,0.0001262251,0.0003577256,0.0001101981,0.0002514964,0.0002389057,0.0002490057,0.0005209042,0.0004046506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003015685,"about_ca_system_score_gemma":0.0002984085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003921133,"about_ca_topic_score_gemma":0.0005330771,"domain_scores_codex":[0.9998773,0.00001891871,0.000009128201,0.00004121937,0.00002573842,0.00002757669],"domain_scores_gemma":[0.9999264,0.00001783645,0.0000238837,0.000008559982,0.00001143928,0.00001181101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002881609,0.000009605928,0.0000304426,0.00003051294,0.000002876962,0.00002184689,0.00001002868,0.00007562633,0.9984754,0.00006750353,0.00002236047,0.001225009],"study_design_scores_gemma":[0.00001247797,0.0002292347,0.0001459647,0.000002955874,0.00001421253,0.00005836542,0.000007974118,0.0005989063,0.9978185,0.00003753155,0.00107197,0.000002028037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9287978,0.004756498,0.06131623,0.0002403656,0.0001036895,0.000204526,0.0002977648,0.0005986189,0.00368456],"genre_scores_gemma":[0.9746654,0.002423236,0.01803198,0.0001546031,0.00003056412,0.0001857215,0.0002729411,0.00007367466,0.0041619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006345798,"threshold_uncertainty_score":0.002188027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02326445968183091,"score_gpt":0.2422302050791,"score_spread":0.2189657453972691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}