{"id":"W2385742736","doi":"10.1038/modpathol.2016.88","title":"Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH","year":2016,"lang":"en","type":"article","venue":"Modern Pathology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":90,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"DOD Prostate Cancer Research Program; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Canary Foundation; Congressionally Directed Medical Research Programs; National Cancer Institute; Prostate Cancer Foundation","keywords":"PTEN; Immunohistochemistry; Prostate cancer; Biology; Cancer research; Immunostaining; Pathology; Cancer; Medicine; PI3K/AKT/mTOR pathway; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006517829,0.0006707906,0.0004614284,0.003620285,0.0007469488,0.001521629,0.001036621,0.000906054,0.002806721],"category_scores_gemma":[0.009774507,0.0004706911,0.0005324071,0.001395199,0.001573184,0.0008367567,0.001214752,0.0006453859,0.0008999552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006108624,"about_ca_system_score_gemma":0.0006268746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00132868,"about_ca_topic_score_gemma":0.002393649,"domain_scores_codex":[0.9951073,0.001164413,0.0005392822,0.001208585,0.001618869,0.0003615924],"domain_scores_gemma":[0.993714,0.002259054,0.001039752,0.0007993028,0.001887748,0.0003001491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001020011,0.0001589083,0.8176935,0.0001918318,0.0004069398,0.0004775418,0.0003594754,0.00146852,0.152602,0.00120131,0.000548341,0.02387156],"study_design_scores_gemma":[0.00009085012,0.0009774698,0.8130422,0.00005989624,0.0009835155,0.005181646,0.0006881643,0.0188068,0.1492988,0.002080956,0.008736563,0.00005310218],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9573697,0.00199022,0.02987625,0.0004310939,0.00009481452,0.0001842614,0.0009064767,0.0003600063,0.008787068],"genre_scores_gemma":[0.9902307,0.0001853353,0.008016892,0.0001136657,0.0000291318,0.0000705378,0.0005953612,0.00003655041,0.0007216957],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.006517829,"threshold_uncertainty_score":0.03446996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05196477560033459,"score_gpt":0.4067279610610453,"score_spread":0.3547631854607107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}