{"id":"W2387584962","doi":"10.1038/srep25823","title":"The small GTPases Ras and Rap1 bind to and control TORC2 activity","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; U.S. Public Health Service; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; American Cancer Society","keywords":"Rap1; Dictyostelium; Small GTPase; Cell biology; Biology; GTPase-activating protein; Cell migration; RHEB; GTPase; Lamellipodium; Signal transduction; Cell; G protein; Gene; PI3K/AKT/mTOR pathway; Genetics; mTORC1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004853764,0.00007278589,0.0000642869,0.00002526212,0.0002921486,0.0001512481,0.00004858397,0.0000397536,0.0000120352],"category_scores_gemma":[0.0002191679,0.00004127798,0.00003319923,0.00004538842,0.0001003614,0.000004778449,0.00008336155,0.00002561862,0.00000328963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006023322,"about_ca_system_score_gemma":0.0000381519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001184566,"about_ca_topic_score_gemma":0.0001222463,"domain_scores_codex":[0.9992321,0.0000270637,0.0001178253,0.0003908482,0.00008124233,0.0001509855],"domain_scores_gemma":[0.9993367,0.00002430355,0.00007001418,0.0003970376,0.00007221415,0.00009970777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001923145,0.00001180355,0.0005190592,0.000001381034,0.0000126413,0.000007846147,0.00001003745,1.771097e-7,0.9829814,0.00003979611,0.004049024,0.01234762],"study_design_scores_gemma":[0.0001182077,0.00006130354,0.0007440949,0.000007448645,0.000007569207,0.00008733822,0.00001407732,0.000009471032,0.5758783,0.0003840816,0.4226173,0.00007081418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937065,0.000377249,0.00287555,0.0009919071,0.001649948,0.0001717015,0.000005109213,0.000005833566,0.0002162414],"genre_scores_gemma":[0.9920584,0.00005377458,0.00003819518,0.00005634115,0.00006637585,0.00001555092,0.000003292834,0.000006653107,0.007701449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4185683,"threshold_uncertainty_score":0.2247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007621992360125047,"score_gpt":0.2219144554062507,"score_spread":0.2142924630461257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}