{"id":"W2387584962","doi":"10.1038/srep25823","title":"The small GTPases Ras and Rap1 bind to and control TORC2 activity","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; U.S. Public Health Service; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; American Cancer Society","keywords":"Rap1; Dictyostelium; Small GTPase; Cell biology; Biology; GTPase-activating protein; Cell migration; RHEB; GTPase; Lamellipodium; Signal transduction; Cell; G protein; Gene; PI3K/AKT/mTOR pathway; Genetics; mTORC1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179158,0.0005924581,0.0002005466,0.0004276818,0.0004733961,0.0005323107,0.0003111888,0.000337785,0.001236512],"category_scores_gemma":[0.000192078,0.0002619882,0.000196615,0.0002787497,0.0004101232,0.0002561983,0.0004916387,0.0003508993,0.0009996464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006031119,"about_ca_system_score_gemma":0.0003498207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100679,"about_ca_topic_score_gemma":0.001383927,"domain_scores_codex":[0.9998339,0.00001451179,0.000007312858,0.00004409154,0.00005431317,0.00004583465],"domain_scores_gemma":[0.9999223,0.000009648937,0.00002692743,0.000007195793,0.00001718828,0.00001675387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846268,0.00001520262,0.0008844938,0.0001197432,0.00001250141,0.0002297928,0.00003194679,0.0003684007,0.9872651,0.001092305,0.0007841403,0.009011681],"study_design_scores_gemma":[0.00003740588,0.00009157562,0.02585098,0.00002207206,0.00002408026,0.00123191,0.0001219891,0.00536827,0.9343624,0.0008336039,0.03202143,0.00003425878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517942,0.0213803,0.009135288,0.0005442009,0.0001516046,0.00004982944,0.001034934,0.0005623803,0.01534722],"genre_scores_gemma":[0.9877556,0.003621901,0.002952505,0.00006556392,0.00003509377,0.00004034733,0.0006751731,0.0000448798,0.004809028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001236512,"threshold_uncertainty_score":0.004375875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007621992360125047,"score_gpt":0.2219144554062507,"score_spread":0.2142924630461257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}