{"id":"W2391377023","doi":"10.1021/acs.jmedchem.5b01578","title":"Synthesis of Tridecaptin–Antibiotic Conjugates with in Vivo Activity against Gram-Negative Bacteria","year":2015,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Alberta Innovates - Health Solutions; Flight Attendant Medical Research Institute","keywords":"Chemistry; Antibiotics; Bacteria; In vivo; Gram-negative bacteria; Gram; Microbiology; Antibacterial agent; Conjugate; Biochemistry; Escherichia coli; Biotechnology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002325489,0.0004994193,0.0004805132,0.0002585965,0.0001629917,0.000248295,0.0002238089,0.0004628742,0.00149441],"category_scores_gemma":[0.0002062568,0.0002452168,0.0002468826,0.0002968971,0.0001346196,0.0003203468,0.0001920137,0.0005571122,0.0005563346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969268,"about_ca_system_score_gemma":0.0001848362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001722878,"about_ca_topic_score_gemma":0.0002881311,"domain_scores_codex":[0.9998263,0.00003683269,0.00002171824,0.00004216035,0.00003801315,0.00003503476],"domain_scores_gemma":[0.9997739,0.00003040531,0.00007882845,0.0000286334,0.00003301176,0.00005528947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001721635,0.00008586737,0.00008641079,0.00005754794,0.00001295887,0.00007548859,0.00001904999,0.0002823245,0.994752,0.00008951729,0.00007002104,0.004296623],"study_design_scores_gemma":[0.00002734848,0.0009116591,0.0005663549,0.000003650883,0.00001903082,0.0002456514,0.000005483459,0.0003342127,0.9960831,0.00001876059,0.0017777,0.000007027148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829046,0.002813656,0.01029714,0.0001280385,0.00006953171,0.0002460589,0.000538467,0.0001877093,0.00281482],"genre_scores_gemma":[0.9835963,0.001808167,0.01054227,0.0000861364,0.00001667494,0.00013003,0.0005269256,0.00003664433,0.003256793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149441,"threshold_uncertainty_score":0.00499928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01975646468840625,"score_gpt":0.2615619570473278,"score_spread":0.2418054923589215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}