{"id":"W2393314843","doi":"10.1126/science.aac7272","title":"Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":401,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital; Sinai Health System; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Princess Margaret Cancer Centre; Children's Hospital of Eastern Ontario; McGill University","funders":"National Cancer Institute; National Institutes of Health; Rockefeller University; National Institute of General Medical Sciences; Greater Milwaukee Foundation; Institute of Genetics; Sidney Kimmel Foundation; Canadian Institutes of Health Research; Rockefeller Foundation; Starr Cancer Consortium","keywords":"Histone; Histone methylation; Chromatin; Mutant; Nucleosome; Histone methyltransferase; Methylation; Histone H3; Biology; Chemistry; Genetics; Cell biology; DNA methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004460408,0.0001118887,0.00009239064,0.00007175064,0.0002375895,0.00002866372,0.0002514402,0.00006557039,0.00005397734],"category_scores_gemma":[0.0002500896,0.00008389949,0.00004812293,0.000298653,0.0003605234,0.00002503891,0.0000854718,0.00002981351,0.00003755688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004692275,"about_ca_system_score_gemma":0.0001594735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001633242,"about_ca_topic_score_gemma":0.00002288094,"domain_scores_codex":[0.9987894,0.0000434127,0.0001941409,0.0004478136,0.0002693176,0.0002559477],"domain_scores_gemma":[0.9992157,0.00001726443,0.0001027413,0.0003945736,0.0001886861,0.00008109299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009793663,0.00002547273,0.0009057628,0.000003115158,0.000004192072,4.255886e-7,0.00009556737,0.00002372639,0.9798625,0.0001281062,0.00008559275,0.01885576],"study_design_scores_gemma":[0.0003074976,0.0001336,0.01629399,0.00000843034,0.00001030439,0.000002062911,0.00001575528,0.00008367893,0.9554577,0.001678138,0.02585083,0.0001580474],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9472566,0.001950839,0.04738525,0.0005692301,0.0003409495,0.0001671917,0.00001482191,0.00002189444,0.002293189],"genre_scores_gemma":[0.9906133,0.0001939343,0.007334338,0.00005467024,0.0001486761,0.00001757713,0.00002496912,0.00001270742,0.00159985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04335665,"threshold_uncertainty_score":0.3421322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193939826047128,"score_gpt":0.323177686186529,"score_spread":0.3037837035818162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}