{"id":"W2393314843","doi":"10.1126/science.aac7272","title":"Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape","year":2016,"lang":"en","type":"article","venue":"Science","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":401,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal General Hospital; Sinai Health System; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Princess Margaret Cancer Centre; Children's Hospital of Eastern Ontario; McGill University","funders":"National Cancer Institute; National Institutes of Health; Rockefeller University; National Institute of General Medical Sciences; Greater Milwaukee Foundation; Institute of Genetics; Sidney Kimmel Foundation; Canadian Institutes of Health Research; Rockefeller Foundation; Starr Cancer Consortium","keywords":"Histone; Histone methylation; Chromatin; Mutant; Nucleosome; Histone methyltransferase; Methylation; Histone H3; Biology; Chemistry; Genetics; Cell biology; DNA methylation; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007817496,0.0001860284,0.0001392112,0.0001709103,0.0001415116,0.0001852899,0.0001094168,0.0001377548,0.001279829],"category_scores_gemma":[0.00009123837,0.0001342644,0.0001671898,0.0001272444,0.0002183207,0.0001063524,0.0002783397,0.0002886279,0.0002858494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045022,"about_ca_system_score_gemma":0.000198347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006398036,"about_ca_topic_score_gemma":0.001300557,"domain_scores_codex":[0.9999247,0.00001176584,0.000008231427,0.00001468192,0.00002181639,0.00001881801],"domain_scores_gemma":[0.9999084,0.00001200258,0.00003867314,0.00001006335,0.000005325848,0.00002545472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001042826,0.00001224943,0.002063473,0.00001700062,0.000006797308,0.0001092323,0.00001499181,0.00008369108,0.9959599,0.000128267,0.00004301442,0.00145724],"study_design_scores_gemma":[0.00002318228,0.0003177455,0.04313108,0.00000552541,0.00002854214,0.001985233,0.00005238939,0.0008631865,0.9507971,0.0002583112,0.002530548,0.000007068948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969597,0.0008390147,0.001154628,0.00004895649,0.00000830533,0.000008194663,0.0001397516,0.00009654554,0.0007449566],"genre_scores_gemma":[0.9987086,0.0003083358,0.0004018813,0.00001160392,0.000001769027,0.000002839983,0.00008307083,0.000006988854,0.0004748971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001279829,"threshold_uncertainty_score":0.004281461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193939826047128,"score_gpt":0.323177686186529,"score_spread":0.3037837035818162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}