{"id":"W2394589397","doi":"10.1038/srep22167","title":"Hyper-active non-homologous end joining selects for synthetic lethality resistant and pathological Fanconi anemia hematopoietic stem and progenitor cells","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; University of Toronto; National Natural Science Foundation of China; University of Rochester; Université Laval; National Cancer Institute; National Institutes of Health; Cincinnati Children's Hospital Medical Center","keywords":"PARP1; FANCA; Fanconi anemia; Synthetic lethality; Progenitor cell; Haematopoiesis; Homologous recombination; Cancer research; DNA damage; Biology; DNA repair; Non-homologous end joining; Stem cell; FANCD2; Cell biology; Poly ADP ribose polymerase; Genetics; DNA; Polymerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001595354,0.0002473953,0.0002236734,0.0003091016,0.0001286036,0.0002436455,0.0002025604,0.00023435,0.001407602],"category_scores_gemma":[0.0001167705,0.0001276229,0.0001204602,0.0001563657,0.0002368413,0.0001083884,0.0002147487,0.0004515907,0.0002740099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001734234,"about_ca_system_score_gemma":0.0001658116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003634133,"about_ca_topic_score_gemma":0.0005313845,"domain_scores_codex":[0.9998174,0.00004122264,0.00002337078,0.00002991113,0.000058507,0.00002961334],"domain_scores_gemma":[0.9998267,0.00003660477,0.00004440581,0.00002362724,0.000009340384,0.0000592936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009230129,0.00006263163,0.0004350574,0.00001175165,0.00000618668,0.00008892059,0.00001262544,0.0001276931,0.9978287,0.0002293212,0.00007123532,0.001033599],"study_design_scores_gemma":[0.00003914995,0.000607452,0.009285981,0.000006644338,0.00002410192,0.001416444,0.0000396462,0.001931294,0.9837118,0.0001171934,0.002811636,0.000008604893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955668,0.0006162619,0.001915061,0.00006738755,0.00001454492,0.00004149134,0.000337726,0.0001090475,0.00133154],"genre_scores_gemma":[0.9968038,0.000270264,0.0008947078,0.00004986992,0.000007207673,0.00002470763,0.0004481552,0.00002313405,0.001478102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001407602,"threshold_uncertainty_score":0.004708886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02460477378023043,"score_gpt":0.2815532780821671,"score_spread":0.2569485043019367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}