{"id":"W2394700887","doi":"10.1097/00019052-200008000-00003","title":"Molecular genetics of Alzheimerʼs disease: the role of β-amyloid and the presenilins","year":2000,"lang":"en","type":"review","venue":"Current Opinion in Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre","funders":"","keywords":"Presenilin; Disease; Pedigree chart; PSEN1; Pathogenesis; Senile plaques; Dementia; Etiology; Alzheimer's disease; Genetics; Medicine; Biology; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006055007,0.001024858,0.001654226,0.001921854,0.0002277586,0.0008890777,0.001106322,0.001231174,0.002458594],"category_scores_gemma":[0.000575945,0.00022365,0.0003131322,0.002414687,0.0005416679,0.0014908,0.0004931848,0.001143204,0.00292885],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007057237,"about_ca_system_score_gemma":0.001037538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278579,"about_ca_topic_score_gemma":0.002049437,"domain_scores_codex":[0.9997874,0.00003787518,0.00002522031,0.00003104074,0.0001017408,0.00001669955],"domain_scores_gemma":[0.9997863,0.00007103859,0.00003865806,0.00000754703,0.00006904879,0.00002749577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006027275,0.00005744556,0.0003014037,0.009279621,0.00008137881,0.0004569772,0.00005454996,0.0002871166,0.002138662,0.002395112,0.04287868,0.9420089],"study_design_scores_gemma":[0.00003371636,0.0000648573,0.002419968,0.003521264,0.0001108135,0.003555263,0.000106117,0.0000717252,0.0003190702,0.003977431,0.9858006,0.00001908457],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001333034,0.9980884,0.0001205022,0.0004934295,0.0002121834,0.000003689658,0.000008155412,0.00000811894,0.0009322602],"genre_scores_gemma":[0.0004607805,0.9984876,0.0001886572,0.0002121935,0.0001618554,0.000003650323,0.00001372688,6.90004e-7,0.0004707547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002458594,"threshold_uncertainty_score":0.008224845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06494617905049804,"score_gpt":0.3922365958003507,"score_spread":0.3272904167498527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}