{"id":"W2394817086","doi":"10.1158/1535-7163.targ-15-b91","title":"Abstract B91: Anti-PD1 blockade increases the activity of tumor infiltrating antigen-specific CD8 T cells induced by a potent peptide vaccine in combination with metronomic cyclophosphamide","year":2015,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"","keywords":"ELISPOT; Immunogenicity; Immune system; Cytotoxic T cell; CD8; Medicine; Immunology; Tumor microenvironment; Cancer vaccine; Antigen; Cancer research; Tumor antigen; Cancer; Immunotherapy; Pharmacology; Biology; Internal medicine; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000136894,0.0005381451,0.0004561122,0.0002305603,0.0001108341,0.0003001215,0.0002225759,0.0003826905,0.00169932],"category_scores_gemma":[0.0001313599,0.0001829607,0.0002234611,0.0001418117,0.0002040735,0.0001846379,0.0001823621,0.001094697,0.0004318029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002055463,"about_ca_system_score_gemma":0.0003003706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003961934,"about_ca_topic_score_gemma":0.0004560504,"domain_scores_codex":[0.999837,0.00003139209,0.00001261801,0.00002966842,0.00002752933,0.00006171647],"domain_scores_gemma":[0.9998955,0.00001675435,0.00002244558,0.00000969795,0.000007712202,0.0000479444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002166837,0.0007450533,0.0001192443,0.00008035636,0.00001593564,0.00003437312,0.00001344038,0.0003935604,0.990927,0.00008659426,0.000233544,0.005184119],"study_design_scores_gemma":[0.0007109623,0.01836527,0.002759434,0.00001866853,0.00004451539,0.000245879,0.00001931323,0.00278765,0.9726211,0.0000656019,0.002351375,0.00001020231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996886,0.0007837907,0.0008152216,0.0001143264,0.00008332614,0.00006315295,0.0002247325,0.00007937897,0.0009501684],"genre_scores_gemma":[0.9971614,0.0003522129,0.000883117,0.00005700301,0.00003820904,0.0000642307,0.0002702037,0.00001448989,0.001159235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169932,"threshold_uncertainty_score":0.005684793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01908011059171164,"score_gpt":0.2490849723117268,"score_spread":0.2300048617200152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}