{"id":"W2394889901","doi":"10.3389/fcell.2016.00050","title":"Gain-of-Function Mutations in the Toll-Like Receptor Pathway: TPL2-Mediated ERK1/ERK2 MAPK Activation, a Path to Tumorigenesis in Lymphoid Neoplasms?","year":2016,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; McGill University Health Centre","keywords":"MAPK/ERK pathway; Signal transduction; TRIF; Biology; Cell biology; Toll-like receptor; Carcinogenesis; Kinase; Cancer research; Anti-apoptotic Ras signalling cascade; Signal transducing adaptor protein; IκB kinase; Phosphorylation; Innate immune system; Receptor; NF-κB; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007728343,0.0003376909,0.0001290262,0.0001747745,0.00008703224,0.0002478744,0.0001543766,0.0003227745,0.001033776],"category_scores_gemma":[0.00009189991,0.00009315606,0.0002238962,0.0001445431,0.0001953777,0.0001811851,0.0001425564,0.0002803005,0.000367414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001847333,"about_ca_system_score_gemma":0.00008962488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001113462,"about_ca_topic_score_gemma":0.0001975618,"domain_scores_codex":[0.9999255,0.00001158671,0.000007104228,0.00001862626,0.00002101169,0.00001613833],"domain_scores_gemma":[0.9999554,0.00000671947,0.00001885207,0.000004185181,0.000003691913,0.00001120687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619587,0.00003089528,0.001029621,0.00003881742,0.00001195462,0.001569016,0.00001471471,0.00009444087,0.9943907,0.0001515037,0.00005777538,0.002448649],"study_design_scores_gemma":[0.00003729338,0.0003878444,0.02177824,0.00001359254,0.0000591129,0.02282205,0.00009252798,0.002115378,0.9484065,0.0002843153,0.003989438,0.00001371473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954618,0.0007386556,0.002262059,0.0001435643,0.00001788635,0.00001895897,0.0002719857,0.00007187855,0.001013204],"genre_scores_gemma":[0.998111,0.0003668206,0.0007324825,0.00002782125,0.000007151447,0.000006707786,0.0001522018,0.00001219479,0.0005835982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033776,"threshold_uncertainty_score":0.003458321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00723062084198388,"score_gpt":0.1965044274647261,"score_spread":0.1892738066227422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}