{"id":"W2395061074","doi":"","title":"HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme.","year":2014,"lang":"en","type":"article","venue":"PubMed","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Staurosporine; Hsp27; Gene knockdown; Viability assay; Cancer research; Apoptosis; Heat shock protein; Hsp90 inhibitor; Cell growth; Biology; Kinase; Pharmacology; Chemistry; Protein kinase C; Hsp90; Cell biology; Hsp70; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005410758,0.0001247526,0.0001549982,0.0001192668,0.00004040667,0.00001779004,0.0001190145,0.0001517264,0.000003465731],"category_scores_gemma":[0.0009597383,0.0001162354,0.00003117997,0.0001845849,0.0001219158,0.000008048986,0.000127573,0.0001143376,0.000001843559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002555878,"about_ca_system_score_gemma":0.00002641619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001563582,"about_ca_topic_score_gemma":0.00007652143,"domain_scores_codex":[0.9987601,0.0001136468,0.0002418659,0.0003581259,0.000179648,0.0003466166],"domain_scores_gemma":[0.9994673,0.00001927641,0.00005980956,0.0002622027,0.00006914978,0.000122239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001133533,0.0001091057,0.003800464,0.00008171105,0.00001640713,3.445422e-7,0.00003262795,0.000009530111,0.7794456,0.0000124402,0.0008995743,0.2154789],"study_design_scores_gemma":[0.0004944913,0.0001620803,0.01169853,0.00001293853,0.000004846462,0.000001850593,0.00002946694,0.00005018013,0.981454,0.00002033158,0.00594229,0.000129009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983526,0.0002835726,0.00008693431,0.0002177508,0.00007856951,0.0006729777,0.00001160498,0.00000875309,0.000287184],"genre_scores_gemma":[0.9986306,0.00006222235,0.00006617836,0.00001933499,0.0001395466,0.0007953896,0.00001844471,0.00001785647,0.0002504727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2153499,"threshold_uncertainty_score":0.4739944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009136523427212603,"score_gpt":0.2288108003345501,"score_spread":0.2196742769073375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}