{"id":"W2395061074","doi":"","title":"HSP27 knockdown produces synergistic induction of apoptosis by HSP90 and kinase inhibitors in glioblastoma multiforme.","year":2014,"lang":"en","type":"article","venue":"PubMed","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Staurosporine; Hsp27; Gene knockdown; Viability assay; Cancer research; Apoptosis; Heat shock protein; Hsp90 inhibitor; Cell growth; Biology; Kinase; Pharmacology; Chemistry; Protein kinase C; Hsp90; Cell biology; Hsp70; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103261,0.0002812787,0.0002526428,0.0002483113,0.0001128762,0.000138377,0.0001391519,0.0001371783,0.001297197],"category_scores_gemma":[0.00006131097,0.0001080623,0.0002312217,0.0001651045,0.0001501562,0.000120819,0.0001591051,0.0002914276,0.0003010371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003384273,"about_ca_system_score_gemma":0.0003045604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398089,"about_ca_topic_score_gemma":0.003556034,"domain_scores_codex":[0.9999286,0.00001071082,0.000006767773,0.00001149202,0.00001904462,0.0000233336],"domain_scores_gemma":[0.9999566,0.000005482244,0.00001143077,0.000006124605,0.000005196254,0.0000151142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002702284,0.00009460512,0.0003306016,0.00005942331,0.00001608226,0.00006319139,0.00001644864,0.0001666673,0.9959234,0.0000713905,0.0002111104,0.002776918],"study_design_scores_gemma":[0.00003470157,0.001008862,0.005651232,0.00000413816,0.00003246854,0.0002248641,0.00002460428,0.0004502915,0.9906736,0.00002301326,0.001869307,0.000002862906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958256,0.001576774,0.0006929279,0.00006637994,0.00001691179,0.00003866694,0.0004425011,0.00006773211,0.001272447],"genre_scores_gemma":[0.9969181,0.0008586952,0.00057004,0.00002563145,0.000003930179,0.00003326022,0.0004585684,0.000009345892,0.001122456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398089,"threshold_uncertainty_score":0.004339576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009136523427212603,"score_gpt":0.2288108003345501,"score_spread":0.2196742769073375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}