{"id":"W2395110963","doi":"10.1158/1557-3265.pmsclingen15-02","title":"Abstract 02: Pan-cancer analysis of hotspot mutations in genes encoding the members of mitogen activated protein kinase (MAPK) and phosphoinosidtide-3 kinase (PI3K) pathways among smokers and non-smokers","year":2016,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"KRAS; PTEN; Neuroblastoma RAS viral oncogene homolog; Medicine; Lung cancer; Cancer research; Oncology; CDKN2A; STK11; Internal medicine; Amplicon; PI3K/AKT/mTOR pathway; Cancer; Gene; Biology; Genetics; Colorectal cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004036356,0.0001561252,0.0002623316,0.00047837,0.0002322573,0.0004911941,0.0002367792,0.000305734,0.005101294],"category_scores_gemma":[0.0005636456,0.0001178927,0.0002466158,0.000488095,0.0001253272,0.0002100124,0.0002549279,0.0002481811,0.0005235471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002058849,"about_ca_system_score_gemma":0.0001672639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118292,"about_ca_topic_score_gemma":0.001802047,"domain_scores_codex":[0.999828,0.00002498309,0.00001553533,0.00006585351,0.00004301276,0.00002265351],"domain_scores_gemma":[0.9996856,0.0000597022,0.00008739642,0.00002716332,0.00005317001,0.00008698764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004823226,0.0001268382,0.9597142,0.00008865853,0.0001843967,0.0001644587,0.00005944401,0.00009344456,0.02343593,0.0000395444,0.001259473,0.01001022],"study_design_scores_gemma":[0.00006184334,0.0004033002,0.9953934,0.00000444574,0.0001014102,0.0005673122,0.00003727772,0.0001687604,0.002550456,0.00003046093,0.0006783931,0.000002914225],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951132,0.0002572452,0.0001845123,0.00003007471,0.000006336743,0.00002645391,0.003515946,0.00002494525,0.0008414141],"genre_scores_gemma":[0.9926016,0.00006712269,0.0002817459,0.00004402962,0.000009355316,0.00003699979,0.005885294,0.00001353668,0.001060418],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005101294,"threshold_uncertainty_score":0.01706553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1194768281916731,"score_gpt":0.4653121906538573,"score_spread":0.3458353624621842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}