{"id":"W2395170454","doi":"10.18632/oncotarget.9642","title":"A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; University of Alberta; Alberta Cancer Foundation","keywords":"Noscapine; Cytotoxicity; Paclitaxel; Tubulin; MTT assay; Alkaloid; Microtubule; Chemistry; Pharmacology; Stereochemistry; Biochemistry; Cell; Biology; In vitro; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951126,0.0001296328,0.0001393986,0.00002338727,0.0000354494,0.00001232086,0.00009243026,0.0001637308,0.0001311074],"category_scores_gemma":[0.0002971508,0.00008273055,0.00005186412,0.0000428149,0.00006335486,0.000004101676,0.00008137212,0.00003721667,0.00002037361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001766296,"about_ca_system_score_gemma":0.00008437592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009000575,"about_ca_topic_score_gemma":0.000009877824,"domain_scores_codex":[0.9991823,0.00006885744,0.000137849,0.0003371107,0.00009600592,0.0001778608],"domain_scores_gemma":[0.9995703,0.00002792176,0.0000473232,0.0001831897,0.00006883738,0.0001024015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006516975,0.00002688557,0.01636594,0.000002259321,0.0000349262,7.622731e-7,0.000012096,3.60031e-7,0.9657103,0.0001155658,0.007334905,0.01033085],"study_design_scores_gemma":[0.0009505539,0.0002175362,0.01299705,0.00002688197,0.00003953147,0.0000241767,0.00001395194,0.0001056608,0.95814,0.0004366692,0.02678469,0.0002633604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912909,0.0007047232,0.006595985,0.0006844072,0.00005891426,0.0001655565,0.00003236666,0.00001113472,0.0004560752],"genre_scores_gemma":[0.9954544,0.000675946,0.003007522,0.0002237927,0.0002864362,0.00002768156,0.00007139498,0.0000112062,0.0002416579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01944978,"threshold_uncertainty_score":0.3373654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606071690870282,"score_gpt":0.2631105385717245,"score_spread":0.2470498216630217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}