{"id":"W2395170454","doi":"10.18632/oncotarget.9642","title":"A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation","year":2016,"lang":"en","type":"article","venue":"Oncotarget","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Allard Foundation; University of Alberta; Alberta Cancer Foundation","keywords":"Noscapine; Cytotoxicity; Paclitaxel; Tubulin; MTT assay; Alkaloid; Microtubule; Chemistry; Pharmacology; Stereochemistry; Biochemistry; Cell; Biology; In vitro; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001115852,0.0004065421,0.0004196873,0.0002404309,0.0001951028,0.0002060094,0.000340007,0.0003804115,0.002916826],"category_scores_gemma":[0.0001514509,0.0001108382,0.0002505338,0.0002794938,0.0001517154,0.0002972857,0.0001843337,0.0005970849,0.0005863648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013602,"about_ca_system_score_gemma":0.0003133935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005960189,"about_ca_topic_score_gemma":0.001348195,"domain_scores_codex":[0.9999261,0.00001006976,0.000006020538,0.00001755779,0.00002705722,0.00001316465],"domain_scores_gemma":[0.9999173,0.000006419007,0.00001451464,0.000005578414,0.00002671779,0.00002942671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005448557,0.000728026,0.0002300883,0.003127837,0.00006280356,0.001033107,0.0001116379,0.002864773,0.9480842,0.000767231,0.001605983,0.04083942],"study_design_scores_gemma":[0.0005283733,0.01705721,0.004666679,0.0002125372,0.0001802646,0.002233381,0.0001133519,0.003489904,0.8819624,0.0003486289,0.08909939,0.0001078307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.865975,0.06611837,0.02336989,0.0008669066,0.0008452231,0.00206167,0.00582212,0.0003596517,0.03458119],"genre_scores_gemma":[0.933596,0.03420756,0.01170774,0.0004783496,0.0001721123,0.000381876,0.002954391,0.00005117664,0.01645092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002916826,"threshold_uncertainty_score":0.009757698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01606071690870282,"score_gpt":0.2631105385717245,"score_spread":0.2470498216630217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}